DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and FBXL4

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001265645.1	Gene:	FBXL4 / 26235	HGNCID:	13601	Length:	621	Species:	Homo sapiens

Alignment Length:	340	Identity:	90/340 - (26%)
Similarity:	136/340 - (40%)	Gaps:	69/340 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 ELLEQIFEHLPVRDLGRAAQVC---------------------------------------TAWR 180
            ||::.|..||.:.||.|.||.|                                       ..|.
Human   286 ELIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQWL 350

  Fly   181 DAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGIKKVQI-LSLRRSLKDLVLGV-----PALTSL 239
            :.:     |.|....:.:...|..|..|    |.:.|:: ||....|.:..|.|     |.|.:|
Human   351 NLS-----WTGNRGFISVAGFSRFLKVC----GSELVRLELSCSHFLNETCLEVISEMCPNLQAL 406

  Fly   240 NLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTG 304
            |||.|..:......|.  ..|.:||.|.|...| :..|:|..|......|:.|.||.|..|.:..
Human   407 NLSSCDKLPPQAFNHI--AKLCSLKRLVLYRTK-VEQTALLSILNFCSELQHLSLGSCVMIEDYD 468

  Fly   305 LL--LIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRL--SDEALG 365
            ::  :|....|||:.|:|..|.:|::.||.       |.|.|...||.|.|..|..|  |.....
Human   469 VIASMIGAKCKKLRTLDLWRCKNITENGIA-------ELASGCPLLEELDLGWCPTLQSSTGCFT 526

  Fly   366 HIAQGLTSLKSINLSFCVSVTDSGLKHLA-RMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLD 429
            .:|..|.:|:.:.|:...||.|:.:..|| ...:|:||::.....:|...:..|.|....::.||
Human   527 RLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLD 591

  Fly   430 VSFCDKISDQALTHI 444
            ||||.:|.::|:..:
Human   592 VSFCSQIDNRAVLEL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	12/73 (16%)
		AMN1	<226..>334	CDD:187754	36/114 (32%)
		leucine-rich repeat	236..256	CDD:275381	7/19 (37%)
		leucine-rich repeat	263..288	CDD:275381	8/24 (33%)
		leucine-rich repeat	289..314	CDD:275381	7/26 (27%)
		leucine-rich repeat	315..347	CDD:275381	10/31 (32%)
		AMN1	347..524	CDD:187754	30/101 (30%)
		leucine-rich repeat	348..373	CDD:275381	9/26 (35%)
		leucine-rich repeat	374..398	CDD:275381	7/24 (29%)
		leucine-rich repeat	399..424	CDD:275381	6/24 (25%)
		leucine-rich repeat	425..450	CDD:275381	8/20 (40%)
		leucine-rich repeat	451..475	CDD:275381
		leucine-rich repeat	476..501	CDD:275381
FBXL4	NP_001265645.1	F-box-like	280..318	CDD:315592	11/31 (35%)
		leucine-rich repeat	295..317	CDD:275381	7/21 (33%)
		leucine-rich repeat	318..346	CDD:275381	0/27 (0%)
		leucine-rich repeat	347..376	CDD:275381	7/37 (19%)
		LRR 1	376..397		6/20 (30%)
		leucine-rich repeat	377..398	CDD:275381	6/20 (30%)
		AMN1	394..601	CDD:332986	66/216 (31%)
		LRR 2	402..421		6/18 (33%)
		leucine-rich repeat	403..427	CDD:275381	8/25 (32%)
		LRR 3	427..448		8/21 (38%)
		leucine-rich repeat	428..452	CDD:275381	8/24 (33%)
		LRR 4	452..474		6/21 (29%)
		leucine-rich repeat	453..480	CDD:275381	7/26 (27%)
		LRR 5	480..501		9/27 (33%)
		leucine-rich repeat	481..506	CDD:275381	10/31 (32%)
		LRR 6	504..524		7/19 (37%)
		leucine-rich repeat	507..534	CDD:275381	9/26 (35%)
		LRR 7	532..558		8/25 (32%)
		leucine-rich repeat	535..560	CDD:275381	7/24 (29%)
		LRR 8	559..583		5/23 (22%)
		leucine-rich repeat	561..586	CDD:275381	6/24 (25%)
		LRR 9	584..609		8/23 (35%)
		leucine-rich repeat	587..612	CDD:275381	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810