DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppa and FBXL6

DIOPT Version :9

Sequence 1:NP_001261138.1 Gene:Ppa / 37602 FlyBaseID:FBgn0020257 Length:562 Species:Drosophila melanogaster
Sequence 2:NP_036294.2 Gene:FBXL6 / 26233 HGNCID:13603 Length:539 Species:Homo sapiens


Alignment Length:525 Identity:138/525 - (26%)
Similarity:202/525 - (38%) Gaps:155/525 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 PGLTRTGATTTHHHLLRFTPYALHHRPPHHQLQTLPPALYLQHAAAAAAAAAAAAAHAQHHHHHH 128
            ||..|..|   .....|.||    .:||........|...|:..||||.|               
Human    52 PGPARPRA---QRRASRRTP----RQPPRGPSAAAKPKAGLRSEAAAAPA--------------- 94

  Fly   129 HHLPHRPASPESPPPVEGTHI--SNLFP-ELLEQIFEHL-----PVRDLGRAAQVCTAWRDAAYA 185
                  ||...:|.|.||...  .:..| |:|.|||..|     |:..|||||:||..|::||..
Human    95 ------PAPAPTPTPEEGPDAGWGDRIPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQ 153

  Fly   186 KSVWK---------------GVEAKLHLKRS----SPSLFNCLVKRGIKKVQILSLRRSLKDLVL 231
            .::|.               ||:|:..|..|    .|:.|:.|     :::.::..:..:..::.
Human   154 PALWHTVTLSSPLVGRPAKGGVKAEKKLLASLEWLMPNRFSQL-----QRLTLIHWKSQVHPVLK 213

  Fly   232 GV----PALTSLNLSGCFNV-AD--MNLGHA----FSVDLPN------------------LKTLD 267
            .|    |.||.|.||||..| ||  :.|..|    .|:||.:                  ::.|.
Human   214 LVGECCPRLTFLKLSGCHGVTADALVMLAKACCQLHSLDLQHSMVESTAVVSFLEEAGSRMRKLW 278

  Fly   268 LSLCKQITDTSLGRIAQHLRNLETLELGGCC------------NITNTGLLLIAWGLKK------ 314
            |:...| |...||.:           ||.||            |..:..|.|....|:|      
Human   279 LTYSSQ-TTAILGAL-----------LGSCCPQLQVLEVSTGINRNSIPLQLPVEALQKGCPQLQ 331

  Fly   315 -LKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQLEYLGL--QDCQRLSDEALGHIAQGLTSLKS 376
             |:.|||  .|.....|.|...|      .|...||.|.|  ..|..:|:|.||.:..|..:|:.
Human   332 VLRLLNL--MWLPKPPGRGVAPG------PGFPSLEELCLASSTCNFVSNEVLGRLLHGSPNLRL 388

  Fly   377 INLSFCVSVTDSGLKHLARMPKLEQLNL---RSCD--NISDIGMAYLTEGG-SGINSLDVS---F 432
            ::|..|..:|.:||:.|. ..:||||:|   .:.|  .::..|..:||:.. ..:..||:|   |
Human   389 LDLRGCARITPAGLQDLP-CRELEQLHLGLYGTSDRLTLAKEGSPFLTQKWCHTLRELDLSGQGF 452

  Fly   433 CDKISDQAL---------THIAQGLYRLRSLSLNQCQITDHGMLKIAKALHELENLNIGQCSRIT 488
            .:|..:|||         :|.|     |.||:|...::|...:..:......|..||:..| |..
Human   453 SEKDLEQALAAFLSTPGGSHPA-----LCSLNLRGTRVTPSTVSSVISGCPGLLYLNLESC-RCL 511

  Fly   489 DKGLQ 493
            .:||:
Human   512 PRGLK 516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpaNP_001261138.1 F-box-like 149..190 CDD:289689 18/48 (38%)
AMN1 <226..>334 CDD:187754 39/155 (25%)
leucine-rich repeat 236..256 CDD:275381 12/26 (46%)
leucine-rich repeat 263..288 CDD:275381 6/24 (25%)
leucine-rich repeat 289..314 CDD:275381 8/36 (22%)
leucine-rich repeat 315..347 CDD:275381 9/31 (29%)
AMN1 347..524 CDD:187754 48/167 (29%)
leucine-rich repeat 348..373 CDD:275381 10/26 (38%)
leucine-rich repeat 374..398 CDD:275381 7/23 (30%)
leucine-rich repeat 399..424 CDD:275381 9/30 (30%)
leucine-rich repeat 425..450 CDD:275381 10/36 (28%)
leucine-rich repeat 451..475 CDD:275381 5/23 (22%)
leucine-rich repeat 476..501 CDD:275381 7/18 (39%)
FBXL6NP_036294.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 49..111 22/86 (26%)
F-box-like 113..163 CDD:289689 19/49 (39%)
LRR 1 177..203 6/30 (20%)
AMN1 185..398 CDD:187754 57/237 (24%)
leucine-rich repeat 196..221 CDD:275381 2/29 (7%)
LRR 2 204..229 6/24 (25%)
leucine-rich repeat 222..247 CDD:275381 12/24 (50%)
LRR 3 230..255 9/24 (38%)
leucine-rich repeat 248..299 CDD:275381 13/62 (21%)
LRR 4 281..307 8/37 (22%)
leucine-rich repeat 300..329 CDD:275381 5/28 (18%)
LRR 5 312..337 5/24 (21%)
leucine-rich repeat 330..357 CDD:275381 9/34 (26%)
LRR 6 341..365 8/29 (28%)
AMN1 <357..508 CDD:187754 44/156 (28%)
leucine-rich repeat 358..385 CDD:275381 10/26 (38%)
LRR 7 368..393 8/24 (33%)
leucine-rich repeat 386..409 CDD:275381 7/23 (30%)
LRR 8 394..419 10/25 (40%)
LRR 9 423..449 5/25 (20%)
leucine-rich repeat 442..474 CDD:275381 9/31 (29%)
LRR 10 453..481 9/32 (28%)
leucine-rich repeat 475..499 CDD:275381 5/23 (22%)
LRR 11 482..507 4/24 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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