DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and rhp7

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_587702.1	Gene:	rhp7 / 2539094	PomBaseID:	SPCC330.02	Length:	563	Species:	Schizosaccharomyces pombe

Alignment Length:	338	Identity:	95/338 - (28%)
Similarity:	153/338 - (45%)	Gaps:	59/338 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 QILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTSLGRI 282
            ||:|..|||.|..:      .|.|||         |..      .||..|   |.:||..||.:|
pombe   222 QIISKNRSLNDTTV------KLFLSG---------GQT------ELKLYD---CSKITADSLFQI 262

  Fly   283 AQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQ 347
            ||:..||:||.|..|..:.:..|...|..|.:|..::.:..:.:|.   .....|.::.....:.
pombe   263 AQYCPNLQTLHLTYCGQMQDQVLHFYADHLTELTDVSFQGAFLVSS---SEWINFFKKRGSKLIS 324

  Fly   348 LEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLNLRSCDNISD 412
            ||   |.|..|:....:..|.....:|.|:|||....:.|..::.||....|..|.:.|...|.:
pombe   325 LE---LTDTARIHVSVINAIVDCCPNLISLNLSRIFYLDDECVRLLAGCRNLVSLKIESPGGIIN 386

  Fly   413 IG--MAYLTEGGSGINSLDVSFCDKISDQALTHIAQGL----YRLRSLSLNQCQ-ITD------H 464
            .|  :..|.:.|||:::|.:|.|.|::|:.|   .||:    .||:.|:|:..: :||      .
pombe   387 DGSILDVLNQIGSGLHTLSLSGCTKLTDEVL---KQGIGPCCGRLKHLNLSGLELLTDDEASIVF 448

  Fly   465 GMLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTN----LKTIDLYGCTQLSSKGIDIIMK-- 523
            |..||...   ||.|::.:|..:.||   |:...|.|    |:|:||.|.:.::.:.:..|:.
pombe   449 GEWKIQSG---LETLSLRRCLSLGDK---TVRAVLVNSGHTLRTLDLNGMSFVTDEALQYIVNFP 507

  Fly   524 LPKLQKLNLGLWL 536
            ||.|:.|::. |:
pombe   508 LPMLKALDVS-WI 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689
		AMN1	<226..>334	CDD:187754	29/107 (27%)
		leucine-rich repeat	236..256	CDD:275381	5/19 (26%)
		leucine-rich repeat	263..288	CDD:275381	11/24 (46%)
		leucine-rich repeat	289..314	CDD:275381	8/24 (33%)
		leucine-rich repeat	315..347	CDD:275381	3/31 (10%)
		AMN1	347..524	CDD:187754	55/195 (28%)
		leucine-rich repeat	348..373	CDD:275381	6/24 (25%)
		leucine-rich repeat	374..398	CDD:275381	8/23 (35%)
		leucine-rich repeat	399..424	CDD:275381	7/26 (27%)
		leucine-rich repeat	425..450	CDD:275381	8/28 (29%)
		leucine-rich repeat	451..475	CDD:275381	8/30 (27%)
		leucine-rich repeat	476..501	CDD:275381	8/24 (33%)
rhp7	NP_587702.1	AMN1	210..452	CDD:187754	73/262 (28%)
		leucine-rich repeat	244..262	CDD:275381	8/26 (31%)
		leucine-rich repeat	269..321	CDD:275381	11/54 (20%)
		leucine-rich repeat	322..347	CDD:275381	6/27 (22%)
		leucine-rich repeat	348..372	CDD:275381	8/23 (35%)
		leucine-rich repeat	373..399	CDD:275381	6/25 (24%)
		leucine-rich repeat	401..427	CDD:275381	8/28 (29%)
		leucine-rich repeat	428..456	CDD:275381	8/27 (30%)
		leucine-rich repeat	457..483	CDD:275381	9/28 (32%)
		leucine-rich repeat	511..536	CDD:275381	3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810