DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and Lrrc29

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001355337.1	Gene:	Lrrc29 / 234684	MGIID:	2443262	Length:	621	Species:	Mus musculus

Alignment Length:	574	Identity:	121/574 - (21%)
Similarity:	198/574 - (34%)	Gaps:	217/574 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 ELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGIKKVQI 219
            |:|..|...||:.|...|:.|...|..||........|...:.:..:|.|....|..|||..:.:
Mouse     8 EMLTYILSFLPLSDQKEASLVSRTWYCAAQNALRETNVRYNIPVSSASLSAIKSLGLRGISCISL 72

  Fly   220 LSL--------------------------------RRSLKDLVLGVPALTSLNLSGC-------- 244
            .:|                                ..|...|:||.|.|.:|:||||
Mouse    73 TNLDGSPASHQVLQSVAYHLGPHLESLCLGGGSPTEASFLALILGCPVLRTLDLSGCNSLFTSGT 137

  Fly   245 --------------------FNVA------DMNLGHAFSVDLPNLKTLDLSLCK----------- 272
                                .|:|      |::..|..|. .|:|:.|.|:.|.
Mouse   138 LLAQPETAQCVREALSGLRDLNLAGLRDLTDLSFNHLSSC-FPSLERLSLAYCHLSFELSPTWGS 201

  Fly   273 ----------------------------------------------QITDTSLGRIAQH-LRNLE 290
                                                          |:|...|..:..| .|:|.
Mouse   202 ISPQVSSPSQLSFHNLLKFIKERAGTLRALDLSGTGLPPEALQALGQVTGLKLEELYLHSCRDLS 266

  Fly   291 ---------------TLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRE 340
                           :|:|.||.::|:..||.::.||:.|:||:|:....::|.|...| |..||
Mouse   267 SEAVTILCRQQPGLTSLDLSGCSDLTDGALLAVSRGLRHLRHLSLKKLQRLTDAGCAAL-GALRE 330

  Fly   341 TAEGNLQLEYLGLQDCQRLSD----EALGHIAQGLTSLKSINLSFCVSVTDSGLKHL--ARMPKL 399
                   |:.|.:.:|..:|.    :.||.:.:...:|.|:.|::|.|:.|:.:..:  |..|.|
Mouse   331 -------LQSLDMAECCLVSGRELAQVLGSVRRAPRALTSLRLAYCSSLKDASVLSMIPALGPSL 388

  Fly   400 EQLNLRS--------------------------CDNISDIGMAYLTE------------------ 420
            :.|:|.|                          |..:.|.|:..|.|
Mouse   389 KVLDLSSCMALTNQTMQAICTYLIHLSVLRLAWCKELQDWGLLGLKEPSDEPVLSPQLHQKVDNE 453

  Fly   421 ------------GGS-----GINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQC-QITDHGML 467
                        |.|     .:..||::.|.|::|.:|..:.| ..:||.|||:.. ..||.|::
Mouse   454 APDPQEPSSEPQGSSLLMLQALQELDLTACSKLTDASLAKVLQ-FPQLRQLSLSLLPAFTDTGLV 517

  Fly   468 KIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGIDII 521
            .:|:....||.|.:..||.::|:|....|.....|:.::|..|:||:.:.:|.|
Mouse   518 AVARGCPSLERLTLSHCSHLSDEGWAQAARLWPRLQHLNLSSCSQLTEQTLDTI 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	11/34 (32%)
		AMN1	<226..>334	CDD:187754	41/214 (19%)
		leucine-rich repeat	236..256	CDD:275381	10/53 (19%)
		leucine-rich repeat	263..288	CDD:275381	8/82 (10%)
		leucine-rich repeat	289..314	CDD:275381	10/39 (26%)
		leucine-rich repeat	315..347	CDD:275381	10/31 (32%)
		AMN1	347..524	CDD:187754	56/243 (23%)
		leucine-rich repeat	348..373	CDD:275381	6/28 (21%)
		leucine-rich repeat	374..398	CDD:275381	7/25 (28%)
		leucine-rich repeat	399..424	CDD:275381	11/85 (13%)
		leucine-rich repeat	425..450	CDD:275381	7/24 (29%)
		leucine-rich repeat	451..475	CDD:275381	9/24 (38%)
		leucine-rich repeat	476..501	CDD:275381	8/24 (33%)
Lrrc29	NP_001355337.1	F-box-like	3..38	CDD:372399	11/29 (38%)
		leucine-rich repeat	70..83	CDD:275381	1/12 (8%)
		LRR_RI	<118..360	CDD:393385	48/250 (19%)
		leucine-rich repeat	121..154	CDD:275381	6/32 (19%)
		leucine-rich repeat	155..180	CDD:275381	5/25 (20%)
		leucine-rich repeat	181..227	CDD:275381	4/45 (9%)
		leucine-rich repeat	228..248	CDD:275381	0/19 (0%)
		AMN1	240..428	CDD:187754	44/195 (23%)
		leucine-rich repeat	254..277	CDD:275381	4/22 (18%)
		leucine-rich repeat	280..305	CDD:275381	9/24 (38%)
		leucine-rich repeat	306..360	CDD:275381	16/61 (26%)
		leucine-rich repeat	331..356	CDD:275381	6/24 (25%)
		leucine-rich repeat	361..387	CDD:275381	7/25 (28%)
		leucine-rich repeat	388..413	CDD:275381	4/24 (17%)
		leucine-rich repeat	414..474	CDD:275381	7/59 (12%)
		AMN1	<475..589	CDD:187754	31/98 (32%)
		leucine-rich repeat	475..525	CDD:275381	16/50 (32%)
		leucine-rich repeat	526..551	CDD:275381	8/24 (33%)
		leucine-rich repeat	552..577	CDD:275381	7/20 (35%)
		leucine-rich repeat	578..603	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810