DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and Fbxl19

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_036008913.1	Gene:	Fbxl19 / 233902	MGIID:	3039600	Length:	696	Species:	Mus musculus

Alignment Length:	339	Identity:	85/339 - (25%)
Similarity:	129/339 - (38%)	Gaps:	94/339 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PHRPASPESPPPVEGTHISNLFPELLE--------------------QIFEHLPVRDLGRAAQVC 176
            |..||.|..||.:| .|:....|...|                    ::|:||..|:|....:||
Mouse   387 PLGPAPPPRPPQLE-RHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCVCMRVC 450

  Fly   177 TAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKR----------GIKKVQILSLRRSLKDLVL 231
            ..|....|.|.:|..::.. ..|..:|.:.:.:|:|          |:.|.|::.|...|:
Mouse   451 RTWSRWCYDKRLWPRMDLS-RRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQ---- 510

  Fly   232 GVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTSL----------------- 279
               .|..|.||||..::...||   |..||.|:.|||...:.:.|:.|
Mouse   511 ---GLQELVLSGCSWLSVSALG---SAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTES 569

  Fly   280 -GRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAE 343
             ||    |:.:..|.|.| ..:|:..|.|:.....:|..|:|..|.|:.|..: ||  .:..|:.
Mouse   570 RGR----LQGVAELRLAG-LELTDASLRLLLRHAPQLSALDLSHCAHVGDPSV-HL--LTAPTSP 626

  Fly   344 GNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLNLRSCD 408
            ....|.:|.|..|.||:|.                   |:.:       ..|.|:|.:|:||||.
Mouse   627 LRETLVHLNLAGCHRLTDH-------------------CLPL-------FRRCPRLRRLDLRSCR 665

  Fly   409 NISDIGMAYLTEGG 422
            .:|....|.|...|
Mouse   666 QLSPEACARLAAAG 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	12/60 (20%)
		AMN1	<226..>334	CDD:187754	33/125 (26%)
		leucine-rich repeat	236..256	CDD:275381	8/19 (42%)
		leucine-rich repeat	263..288	CDD:275381	9/42 (21%)
		leucine-rich repeat	289..314	CDD:275381	6/24 (25%)
		leucine-rich repeat	315..347	CDD:275381	9/31 (29%)
		AMN1	347..524	CDD:187754	20/76 (26%)
		leucine-rich repeat	348..373	CDD:275381	7/24 (29%)
		leucine-rich repeat	374..398	CDD:275381	2/23 (9%)
		leucine-rich repeat	399..424	CDD:275381	10/24 (42%)
		leucine-rich repeat	425..450	CDD:275381
		leucine-rich repeat	451..475	CDD:275381
		leucine-rich repeat	476..501	CDD:275381
Fbxl19	XP_036008913.1	zf-CXXC	<52..79	CDD:366873
		PHD_FXL19	89..150	CDD:277115
		F-box-like	426..467	CDD:403981	11/40 (28%)
		AMN1	468..667	CDD:187754	60/243 (25%)
		leucine-rich repeat	488..511	CDD:275381	5/29 (17%)
		leucine-rich repeat	512..535	CDD:275381	10/25 (40%)
		leucine-rich repeat	573..600	CDD:275381	7/27 (26%)
		leucine-rich repeat	601..627	CDD:275381	9/28 (32%)
		leucine-rich repeat	631..655	CDD:275381	9/49 (18%)
		leucine-rich repeat	656..680	CDD:275381	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810