DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and Amn1

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001106895.1	Gene:	Amn1 / 232566	MGIID:	2442933	Length:	258	Species:	Mus musculus

Alignment Length:	277	Identity:	60/277 - (21%)
Similarity:	127/277 - (45%)	Gaps:	37/277 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 LSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIG 332
            |.||.|....::.|....::.|.:       ||.:          :.:|.:::|.  .|:|..|.
Mouse    11 LELCLQYLVINISRYISDIKYLPS-------NIKD----------RLIKIMSIRG--RITDSNIS 56

  Fly   333 HLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFC----VSVTDSGLKHL 393
            .:.         :.:::.|.|:.|. :||.||.|:.: ...||::||..|    .|:|..|:|.:
Mouse    57 EVL---------HPEVQRLDLRSCD-ISDVALQHLCK-CRKLKALNLKSCREHRNSITSEGIKAV 110

  Fly   394 A-RMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLN 457
            | ....|.::.|:.|.:::|.|:..|......:..:|:..|..|:|.:|..:.:....|:.:.::
Mouse   111 ASSCSDLHEIYLKGCCSVTDEGVLALALNCHLLKIIDLGGCLGITDVSLHALGKNCPFLQCVDIS 175

  Fly   458 QCQITDHGMLKIAK--ALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGIDI 520
            ..|::|:|::.:..  ...:||.:|:..|..:|||.::........:..:..:||..::.:..::
Mouse   176 TTQVSDNGVVALVSGPCAKQLEEINMRYCINLTDKAVEAALTACPRICILLFHGCPLITDRSQEV 240

  Fly   521 IMKLPKLQKLNLGLWLV 537
            :.:|...:||....|.|
Mouse   241 LEQLIGSRKLKQVTWSV 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689
		AMN1	<226..>334	CDD:187754	13/65 (20%)
		leucine-rich repeat	236..256	CDD:275381
		leucine-rich repeat	263..288	CDD:275381	5/19 (26%)
		leucine-rich repeat	289..314	CDD:275381	3/24 (13%)
		leucine-rich repeat	315..347	CDD:275381	5/31 (16%)
		AMN1	347..524	CDD:187754	42/183 (23%)
		leucine-rich repeat	348..373	CDD:275381	8/24 (33%)
		leucine-rich repeat	374..398	CDD:275381	10/28 (36%)
		leucine-rich repeat	399..424	CDD:275381	6/24 (25%)
		leucine-rich repeat	425..450	CDD:275381	5/24 (21%)
		leucine-rich repeat	451..475	CDD:275381	4/25 (16%)
		leucine-rich repeat	476..501	CDD:275381	7/24 (29%)
Amn1	NP_001106895.1	leucine-rich repeat	15..38	CDD:275381	5/29 (17%)
		AMN1	37..257	CDD:187754	51/242 (21%)
		leucine-rich repeat	63..86	CDD:275381	8/24 (33%)
		leucine-rich repeat	87..116	CDD:275381	10/28 (36%)
		leucine-rich repeat	117..142	CDD:275381	6/24 (25%)
		leucine-rich repeat	143..168	CDD:275381	5/24 (21%)
		leucine-rich repeat	169..195	CDD:275381	4/25 (16%)
		leucine-rich repeat	196..221	CDD:275381	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900