DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and KDM2A

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_036440.1	Gene:	KDM2A / 22992	HGNCID:	13606	Length:	1162	Species:	Homo sapiens

Alignment Length:	310	Identity:	79/310 - (25%)
Similarity:	122/310 - (39%)	Gaps:	71/310 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 ELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSS---PSLFNCLVKRGIKK 216
            |:...:|.:|..|:|....:||..|......|.:|    .|:.|.|..   |...:.::||
Human   896 EVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLW----TKIDLSRCKAIVPQALSGIIKR---- 952

  Fly   217 VQILSL--------RRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQ 273
             |.:||        ::.|..||..:|.|..|.|:||...|...|.   :...|.|:||||.....
Human   953 -QPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALS---TSSCPLLRTLDLRWAVG 1013

  Fly   274 ITDTSLGRI------------AQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHI 326
            |.|..:..:            ...|||:....|.| .:||:..|.||...:..|..|:|..|.|:
Human  1014 IKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAG-LDITDATLRLIIRHMPLLSRLDLSHCSHL 1077

  Fly   327 SDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLK 391
            :||....|......|   ...|..|.:..|.:|:|:.|.::.: :.::..|:|..|..:|....:
Human  1078 TDQSSNLLTAVGSST---RYSLTELNMAGCNKLTDQTLIYLRR-IANVTLIDLRGCKQITRKACE 1138

  Fly   392 HLARMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQAL 441
            |.                |||:          .||||   :|  :||:.|
Human  1139 HF----------------ISDL----------SINSL---YC--LSDEKL 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	9/34 (26%)
		AMN1	<226..>334	CDD:187754	36/119 (30%)
		leucine-rich repeat	236..256	CDD:275381	7/19 (37%)
		leucine-rich repeat	263..288	CDD:275381	8/36 (22%)
		leucine-rich repeat	289..314	CDD:275381	7/24 (29%)
		leucine-rich repeat	315..347	CDD:275381	9/31 (29%)
		AMN1	347..524	CDD:187754	22/95 (23%)
		leucine-rich repeat	348..373	CDD:275381	6/24 (25%)
		leucine-rich repeat	374..398	CDD:275381	5/23 (22%)
		leucine-rich repeat	399..424	CDD:275381	3/24 (13%)
		leucine-rich repeat	425..450	CDD:275381	8/17 (47%)
		leucine-rich repeat	451..475	CDD:275381
		leucine-rich repeat	476..501	CDD:275381
KDM2A	NP_036440.1	cupin_like	199..299	CDD:328732
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..389
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..557
		zf-CXXC	<576..609	CDD:251032
		PHD_KDM2A	619..675	CDD:277113
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..789
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	839..887
		F-box-like	896..934	CDD:315592	11/41 (27%)
		leucine-rich repeat	930..954	CDD:275381	7/32 (22%)
		AMN1	932..1138	CDD:332986	57/218 (26%)
		leucine-rich repeat	955..978	CDD:275381	5/22 (23%)
		LRR 1	961..982		5/20 (25%)
		leucine-rich repeat	979..1002	CDD:275381	7/25 (28%)
		LRR 2	984..1010		11/28 (39%)
		leucine-rich repeat	1003..1040	CDD:275381	8/36 (22%)
		leucine-rich repeat	1041..1065	CDD:275381	7/24 (29%)
		LRR 3	1048..1073		9/25 (36%)
		leucine-rich repeat	1066..1095	CDD:275381	9/31 (29%)
		LRR 4	1074..1103		8/31 (26%)
		leucine-rich repeat	1096..1120	CDD:275381	6/24 (25%)
		LRR 5	1104..1128		6/24 (25%)
		leucine-rich repeat	1121..1140	CDD:275381	4/18 (22%)
		LRR 6	1129..1156		13/57 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810