DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and Kdm2a

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001001984.2	Gene:	Kdm2a / 225876	MGIID:	1354736	Length:	1161	Species:	Mus musculus

Alignment Length:	310	Identity:	78/310 - (25%)
Similarity:	121/310 - (39%)	Gaps:	71/310 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 ELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSS---PSLFNCLVKRGIKK 216
            |:...:|.:|..::|....:||..|......|.:|    .|:.|.|..   |...:.::||
Mouse   895 EVWMSVFRYLSRKELCECMRVCKTWYKWCCDKRLW----TKIDLSRCKAIVPQALSGIIKR---- 951

  Fly   217 VQILSL--------RRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQ 273
             |.:||        ::.|..||..:|.|..|.|:||...|...|.   :...|.|:||||.....
Mouse   952 -QPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALS---TSSCPLLRTLDLRWAVG 1012

  Fly   274 ITDTSLGRI------------AQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHI 326
            |.|..:..:            ...|||:....|.| .:||:..|.||...:..|..|:|..|.|:
Mouse  1013 IKDPQIRDLLTPPTDKPGQDNRSKLRNMTDFRLAG-LDITDATLRLIIRHMPLLSRLDLSHCSHL 1076

  Fly   327 SDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLK 391
            :||....|......|   ...|..|.:..|.:|:|:.|..:.: :.::..|:|..|..:|....:
Mouse  1077 TDQSSNLLTAVGSST---RYSLTELNMAGCNKLTDQTLFFLRR-IANVTLIDLRGCKQITRKACE 1137

  Fly   392 HLARMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQAL 441
            |.                |||:          .||||   :|  :||:.|
Mouse  1138 HF----------------ISDL----------SINSL---YC--LSDEKL 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	8/34 (24%)
		AMN1	<226..>334	CDD:187754	36/119 (30%)
		leucine-rich repeat	236..256	CDD:275381	7/19 (37%)
		leucine-rich repeat	263..288	CDD:275381	8/36 (22%)
		leucine-rich repeat	289..314	CDD:275381	7/24 (29%)
		leucine-rich repeat	315..347	CDD:275381	9/31 (29%)
		AMN1	347..524	CDD:187754	22/95 (23%)
		leucine-rich repeat	348..373	CDD:275381	6/24 (25%)
		leucine-rich repeat	374..398	CDD:275381	5/23 (22%)
		leucine-rich repeat	399..424	CDD:275381	3/24 (13%)
		leucine-rich repeat	425..450	CDD:275381	8/17 (47%)
		leucine-rich repeat	451..475	CDD:275381
		leucine-rich repeat	476..501	CDD:275381
Kdm2a	NP_001001984.2	cupin_like	199..299	CDD:389752
		JHD	304..>339	CDD:375347
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..445
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..557
		zf-CXXC	<576..609	CDD:366873
		PHD_KDM2A	619..675	CDD:277113
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	705..789
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..886
		F-box-like	895..933	CDD:372399	10/41 (24%)
		leucine-rich repeat	929..953	CDD:275381	7/32 (22%)
		AMN1	931..1137	CDD:187754	57/218 (26%)
		leucine-rich repeat	954..977	CDD:275381	5/22 (23%)
		LRR 1	960..981		5/20 (25%)
		leucine-rich repeat	978..1001	CDD:275381	7/25 (28%)
		LRR 2	983..1009		11/28 (39%)
		leucine-rich repeat	1002..1039	CDD:275381	8/36 (22%)
		leucine-rich repeat	1040..1064	CDD:275381	7/24 (29%)
		LRR 3	1047..1072		9/25 (36%)
		leucine-rich repeat	1065..1094	CDD:275381	9/31 (29%)
		LRR 4	1073..1102		8/31 (26%)
		leucine-rich repeat	1095..1119	CDD:275381	6/24 (25%)
		LRR 5	1103..1127		6/24 (25%)
		leucine-rich repeat	1120..1139	CDD:275381	4/18 (22%)
		LRR 6	1128..1155		13/57 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810