DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and FBXL13

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001381423.1	Gene:	FBXL13 / 222235	HGNCID:	21658	Length:	825	Species:	Homo sapiens

Alignment Length:	483	Identity:	118/483 - (24%)
Similarity:	204/483 - (42%)	Gaps:	115/483 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 NLFPE-LLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLF-------- 206
            :|.|| .:.|||.:|.::|:....||..||.......|:|..::.. .:|...|..:
Human   246 SLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFS-SVKNVIPDKYIVSTLQRW 309

  Fly   207 ----------NCLVKRGIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLP 261
                      .||::.  |..:.:|..|:|::          ||:|.|....|.::.| .|...|
Human   310 RLNVLRLNFRGCLLRP--KTFRSVSHCRNLQE----------LNVSDCPTFTDESMRH-ISEGCP 361

  Fly   262 NLKTLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGL--LLIAWGLKKLKHLNLRSCW 324
            .:..|:|| ...||:.::..:.:|..||:.|.|..|...|:.||  |.:..|..||.:|:|..|.
Human   362 GVLCLNLS-NTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCT 425

  Fly   325 HISDQGIGHLAG---------------------------FSRETA-------------------- 342
            .||.||..::|.                           .||.|:
Human   426 QISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSAC 490

  Fly   343 -------EGNLQ---------------LEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSV 385
                   |||.:               |.::.:.||:.::|.:|..::. |..|..:||:.||.:
Human   491 KLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSP-LKQLTVLNLANCVRI 554

  Fly   386 TDSGLKHLARMP---KLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQG 447
            .|.|||.....|   ::.:|||.:|..:||..:..|:|....:|.|.:..|:.::.|.:.:|. .
Human   555 GDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIV-N 618

  Fly   448 LYRLRSLSLNQCQITDHGMLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQ 512
            ::.|.|:.|:...|::.| |.:.....:|:.|::.:|.||||.|:|...:....|:.:|:..|:|
Human   619 IFSLVSIDLSGTDISNEG-LNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQ 682

  Fly   513 LSSKGIDIIMKLPKLQKLNLGLWLVRXC 540
            ||    |:|:|...:..:||....:..|
Human   683 LS----DMIIKALAIYCINLTSLSIAGC 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	13/39 (33%)
		AMN1	<226..>334	CDD:187754	34/109 (31%)
		leucine-rich repeat	236..256	CDD:275381	6/19 (32%)
		leucine-rich repeat	263..288	CDD:275381	6/24 (25%)
		leucine-rich repeat	289..314	CDD:275381	9/26 (35%)
		leucine-rich repeat	315..347	CDD:275381	15/85 (18%)
		AMN1	347..524	CDD:187754	52/194 (27%)
		leucine-rich repeat	348..373	CDD:275381	6/24 (25%)
		leucine-rich repeat	374..398	CDD:275381	10/26 (38%)
		leucine-rich repeat	399..424	CDD:275381	8/24 (33%)
		leucine-rich repeat	425..450	CDD:275381	5/24 (21%)
		leucine-rich repeat	451..475	CDD:275381	6/23 (26%)
		leucine-rich repeat	476..501	CDD:275381	9/24 (38%)
FBXL13	NP_001381423.1	Sfi1	<112..>224	CDD:400658
		F-box-like	245..289	CDD:403981	14/42 (33%)
		leucine-rich repeat	285..312	CDD:275381	3/27 (11%)
		AMN1	312..497	CDD:187754	43/198 (22%)
		leucine-rich repeat	313..336	CDD:275381	4/24 (17%)
		leucine-rich repeat	337..362	CDD:275381	8/35 (23%)
		leucine-rich repeat	363..387	CDD:275381	6/24 (25%)
		leucine-rich repeat	388..406	CDD:275381	7/17 (41%)
		leucine-rich repeat	416..441	CDD:275381	9/24 (38%)
		leucine-rich repeat	442..491	CDD:275381	3/48 (6%)
		leucine-rich repeat	468..490	CDD:275381	1/21 (5%)
		leucine-rich repeat	492..515	CDD:275381	3/22 (14%)
		leucine-rich repeat	518..542	CDD:275381	6/24 (25%)
		AMN1	529..737	CDD:187754	53/185 (29%)
		leucine-rich repeat	543..570	CDD:275381	10/26 (38%)
		leucine-rich repeat	571..596	CDD:275381	8/24 (33%)
		leucine-rich repeat	597..645	CDD:275381	11/49 (22%)
		leucine-rich repeat	646..671	CDD:275381	9/24 (38%)
		leucine-rich repeat	672..697	CDD:275381	9/28 (32%)
		leucine-rich repeat	698..723	CDD:275381	2/9 (22%)
		leucine-rich repeat	724..749	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820