DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and Fbxl16

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001366323.1	Gene:	Fbxl16 / 214931	MGIID:	2448488	Length:	575	Species:	Mus musculus

Alignment Length:	497	Identity:	135/497 - (27%)
Similarity:	222/497 - (44%)	Gaps:	90/497 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 ELPGLTR-TGATTTHHHLLRFTPYALHH--RPPHHQLQTLPP---ALYLQHAAAAAAAAAAAAAH 120
            :|||... .||.:    :.:.||.|.:.  :||  ...||||   |..|...|.|......|:.
Mouse   118 KLPGQPNGLGAAS----ITKGTPAAKNRPCQPP--PPPTLPPPSLATPLSRVALAGGPCPPASG- 175

  Fly   121 AQHHHHHHHHLPHRPAS-PESPPPVEGTHISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAY 184
                          ||| |.|.||||...::. ..::|..:|.:....:....||||.|||...|
Mouse   176 --------------PASGPVSGPPVERPPLAT-DEKILNGLFWYFSACEKCILAQVCKAWRRVLY 225

  Fly   185 AKSVWKGVEAKLHLKRSSPSLFNCLVKRGIKKVQILSLRRSLKDLVLGVPALTSLNLSG------ 243
            ....|.|:...||.|    .|:|.| ..|.|:.                     :||.|
Mouse   226 QPKFWAGLTPVLHAK----ELYNVL-PGGEKEF---------------------VNLQGFAARGF 264

  Fly   244 ---CF-NVADMNLGH---AFSVDLPNLKTLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCNIT 301
               |. .|:|:::..   .:|:....:|.:.|.. ..|||..|..:.:.::.:..|||.||.:.|
Mouse   265 EGFCLVGVSDLDICEFIDNYSLSKKGVKAMSLKR-STITDAGLEVMLEQMQGVVRLELSGCNDFT 328

  Fly   302 NTGLLLIAWG--LKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEAL 364
            ..||    |.  ..::..|::..|.:::|..|..::......||.:||        ...::|.||
Mouse   329 EAGL----WSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQ--------AYHVTDTAL 381

  Fly   365 GHIA--QGLTSLKSINLSFCVSVTDSGLKHLAR-MPKLEQLNLRSCDNISDIGMAYLTEGGSGIN 426
            .:..  || .|..::.|..|..:|:.|:.::.. :|.|..|:|..|..::|.|:..:.|....:.
Mouse   382 AYFTARQG-HSTHTLRLLSCWEITNHGVVNVVHSLPNLTSLSLSGCSKVTDDGVELVAENLRKLR 445

  Fly   427 SLDVSFCDKISDQALTHIAQGLYRLRSLSLNQC-QITDHGMLKIAKALHELENLNIGQCSRITDK 490
            |||:|:|.:|:|.||.::|..|:||..|.|::| :|||.| |.....:..|.:|.:..|.::.|.
Mouse   446 SLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTG-LSYLSTMSSLRSLYLRWCCQVQDF 509

  Fly   491 GLQTLAEDLTNLKTIDLYGCTQLSSKGIDIIMKLPKLQKLNL 532
            ||:.|.. :.||:.:.|.||..|::.|:..:::|.:|::|.|
Mouse   510 GLKHLLA-MRNLRLLSLAGCPLLTTTGLSGLVQLQELEELEL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	10/40 (25%)
		AMN1	<226..>334	CDD:187754	26/122 (21%)
		leucine-rich repeat	236..256	CDD:275381	6/32 (19%)
		leucine-rich repeat	263..288	CDD:275381	6/24 (25%)
		leucine-rich repeat	289..314	CDD:275381	9/26 (35%)
		leucine-rich repeat	315..347	CDD:275381	6/31 (19%)
		AMN1	347..524	CDD:187754	54/180 (30%)
		leucine-rich repeat	348..373	CDD:275381	5/26 (19%)
		leucine-rich repeat	374..398	CDD:275381	4/24 (17%)
		leucine-rich repeat	399..424	CDD:275381	7/24 (29%)
		leucine-rich repeat	425..450	CDD:275381	11/24 (46%)
		leucine-rich repeat	451..475	CDD:275381	9/24 (38%)
		leucine-rich repeat	476..501	CDD:275381	7/24 (29%)
Fbxl16	NP_001366323.1	PHA03247	<31..193	CDD:223021	28/95 (29%)
		AMN1	297..509	CDD:187754	63/226 (28%)
		leucine-rich repeat	316..339	CDD:275381	9/26 (35%)
		leucine-rich repeat	340..365	CDD:275381	4/24 (17%)
		leucine-rich repeat	366..391	CDD:275381	9/33 (27%)
		leucine-rich repeat	392..417	CDD:275381	4/24 (17%)
		leucine-rich repeat	418..443	CDD:275381	7/24 (29%)
		leucine-rich repeat	444..469	CDD:275381	11/24 (46%)
		leucine-rich repeat	470..494	CDD:275381	9/24 (38%)
		leucine-rich repeat	495..514	CDD:275381	6/18 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820