DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and Fbxl21

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001333661.1	Gene:	Fbxl21 / 213311	MGIID:	2442921	Length:	460	Species:	Mus musculus

Alignment Length:	414	Identity:	93/414 - (22%)
Similarity:	160/414 - (38%)	Gaps:	118/414 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 ASPESPPPVEG-------THISNLFPE-------LLEQIFEHLPVRDLGRAAQVCTAWRDAAYAK 186
            :||....|..|       ||..::..:       ::.|||::||:.|..||:.||..|.:..:..
Mouse    41 SSPVVKQPKRGLCSSLRQTHALSVLLDWGTLPHHVILQIFQYLPLIDRARASSVCRRWNEVFHIP 105

  Fly   187 SVWKGVEAKL------HLKRSSPSLFNCLVKRGIKKVQILSLRRS------------LKDLV--- 230
            .:|:..|.:|      :.|.:.|.|...::|:....:|.:|.:..            |..||
Mouse   106 DLWRKFEFELNQSATSYFKSTHPDLIQQIIKKHAAHLQYVSFKVDSSTESAEAACDILSQLVNCS 170

  Fly   231 ---LGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTSLG------RIAQHL 286
               ||   |.|.......||...:...|.:|...|.|:|. |:  :|.||.:.      .:|.:.
Mouse   171 IQTLG---LISTAKPSFMNVPKSHFVSALTVVFVNSKSLS-SI--KIEDTPVDDPSLKILVANNS 229

  Fly   287 RNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQLEYL 351
            ..|..|::..|.::::.|:|.:|...:.|:.|.| :.:.:||:   .|...|.||   ::.||:|
Mouse   230 DTLRLLKMSSCPHVSSDGILCVADHCQGLRELAL-NYYILSDE---ILLALSSET---HVNLEHL 287

  Fly   352 GLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLNL------------ 404
            .:.    :..|..|.|.  ..|:|..:       .|:.:||..|:..:....|
Mouse   288 RID----VVSENPGQIK--FHSIKKRS-------WDALIKHSPRVNVVMYFFLYEEEFEAFFKEE 339

  Fly   405 ---------RSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQ 460
                     ||      :..|.|  |..|:|      |.::.:  |...|.||..|
Mouse   340 TPVTHLYFGRS------VSRAIL--GRIGLN------CPRLIE--LVVCANGLLPL--------- 379

  Fly   461 ITDHGMLKIAKALHELENLNIGQC 484
              |..:::|||....|.:|.:.:|
Mouse   380 --DSELIRIAKHCKNLTSLGLSEC 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	11/47 (23%)
		AMN1	<226..>334	CDD:187754	30/119 (25%)
		leucine-rich repeat	236..256	CDD:275381	4/19 (21%)
		leucine-rich repeat	263..288	CDD:275381	7/30 (23%)
		leucine-rich repeat	289..314	CDD:275381	6/24 (25%)
		leucine-rich repeat	315..347	CDD:275381	9/31 (29%)
		AMN1	347..524	CDD:187754	33/159 (21%)
		leucine-rich repeat	348..373	CDD:275381	6/24 (25%)
		leucine-rich repeat	374..398	CDD:275381	5/23 (22%)
		leucine-rich repeat	399..424	CDD:275381	6/45 (13%)
		leucine-rich repeat	425..450	CDD:275381	6/24 (25%)
		leucine-rich repeat	451..475	CDD:275381	5/23 (22%)
		leucine-rich repeat	476..501	CDD:275381	3/9 (33%)
Fbxl21	NP_001333661.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810