DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and zeel-1

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_490966.2	Gene:	zeel-1 / 189770	WormBaseID:	WBGene00021463	Length:	917	Species:	Caenorhabditis elegans

Alignment Length:	509	Identity:	94/509 - (18%)
Similarity:	180/509 - (35%)	Gaps:	179/509 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 HHHHHHHHLPHRPASPESPPPVEGTHISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAK- 186
            :|.:..:.|||:..|          .::|:                  .|||:.....|..|.:
Worm   209 NHCNTAYRLPHKMTS----------SLANI------------------TAAQIARHINDGRYTRT 245

  Fly   187 SVWKGVEAKLH------LKRSSPSLFNCLVK-----------RGIKKVQILSLRRSLKDLVLGVP 234
            ::.:|::.|..      |...:|..:..:.|           :.:.:::..:..:|:      :.
Worm   246 NILEGMDTKFRDTILSKLLLLNPKAYQFIAKTTQVEKSLSIGKRVFELEYYARHKSI------IT 304

  Fly   235 ALT-------------SLNLSGCFNVADMNLG--HAFSVDLPNLKTLDLSLCKQITDTSLGRIAQ 284
            .||             .|::..|  .|.:..|  ....:.|.:|.||::| .|.::......:..
Worm   305 TLTIVLHKKKYWEKIQKLDIREC--EAQLTPGWVKQIGIMLSSLTTLEIS-NKPLSKEDFSELCD 366

  Fly   285 HLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQLE 349
            ...||..|:      |::||:..:. |:.|||||.:  .|                  ..|||.|
Worm   367 SFPNLVQLD------ISDTGIRKLD-GIFKLKHLKV--LW------------------MRNLQFE 404

  Fly   350 YLG-LQDCQRLSDEALGHIAQGL--TSLKSI-----------NLSFC-VSVTDSG---LKHLARM 396
            ... :.|..:|:......:::.:  |::|:|           ||:|. .|.||..   |..||..
Worm   405 CSSDMLDLFKLTGLTALDVSRDVYKTNIKTIMQFVECGIILPNLTFLDASGTDLNENLLNSLASH 469

  Fly   397 PKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCD-KISDQALTHIAQGLYRLRSLSLNQCQ 460
            |||:|:      ...|..:.|:...|..|    :||.: :.|.:.|.|...   ..||::..:|
Worm   470 PKLQQI------VAIDTNVQYIKTTGHEI----LSFGNLQTSLRILKHFVN---LKRSVATRKC- 520

  Fly   461 ITDHGMLKIAKALHELEN----LNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSK----- 516
                 :|:|...|.:..|    .::.:|.|...:.::|...:            .||.::
Worm   521 -----LLRITTQLKQFHNDTKQYDVVKCLRHAIEAIETFRPN------------EQLKAEIRWND 568

  Fly   517 -----GIDIIMKL---------PKLQKLNLGLWLV---------RXCVHHDCNA 547
                 |::.::::         |...||.|.:.|:         ...:.|.|.|
Worm   569 NTYITGLNCLIEISRNKSHIFHPLDAKLVLDILLIASERILPLTSSALQHPCQA 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	6/41 (15%)
		AMN1	<226..>334	CDD:187754	25/122 (20%)
		leucine-rich repeat	236..256	CDD:275381	6/34 (18%)
		leucine-rich repeat	263..288	CDD:275381	5/24 (21%)
		leucine-rich repeat	289..314	CDD:275381	6/24 (25%)
		leucine-rich repeat	315..347	CDD:275381	6/31 (19%)
		AMN1	347..524	CDD:187754	42/209 (20%)
		leucine-rich repeat	348..373	CDD:275381	3/27 (11%)
		leucine-rich repeat	374..398	CDD:275381	11/38 (29%)
		leucine-rich repeat	399..424	CDD:275381	5/24 (21%)
		leucine-rich repeat	425..450	CDD:275381	6/25 (24%)
		leucine-rich repeat	451..475	CDD:275381	6/23 (26%)
		leucine-rich repeat	476..501	CDD:275381	4/28 (14%)
zeel-1	NP_490966.2	leucine-rich repeat	346..370	CDD:275380	5/24 (21%)
		leucine-rich repeat	371..392	CDD:275380	8/27 (30%)
		leucine-rich repeat	393..417	CDD:275380	8/43 (19%)
		leucine-rich repeat	418..447	CDD:275380	3/28 (11%)
		leucine-rich repeat	448..471	CDD:275380	8/22 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162694
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930