DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and K05C4.9

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001362175.1	Gene:	K05C4.9 / 187021	WormBaseID:	WBGene00010585	Length:	718	Species:	Caenorhabditis elegans

Alignment Length:	328	Identity:	66/328 - (20%)
Similarity:	121/328 - (36%)	Gaps:	81/328 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 NLGHAFSVDLP-------------NLKTLDL---SLCKQITDTSLGRIAQHLRNLETLELGG--- 296
            ||.:|..:.:|             ||..:||   :||....:     :.:..|.||:|.||.
Worm    37 NLIYAAFIKIPTSKKAIRIPELVLNLTNVDLRNTTLCHNTIE-----MLRTQRTLESLALGSLLL 96

  Fly   297 -----CCNITNTGLLLIAWGL------KKLKHLNLRSCWHISDQGIGHL-AGFSRETAEGNLQLE 349
                 .|....|.::.:...:      |:|:|||:|        |.|.: .|:|.:.:|....|:
Worm    97 IKKDYLCETGRTNIVALLKDILNEKSRKRLRHLNIR--------GAGLIGCGWSDKLSELFPSLK 153

  Fly   350 YLGLQDCQRLSDEALG---------------------HIAQGLTSLKSINLSFCVSVTDSGLKHL 393
            .|.:.:....:||.|.                     |....|.:|:.:::.:......:.|..|
Worm   154 TLNVSNILFENDELLRLCVSFPSLCVLDISGTNIASLHGLSNLKNLQELSIRYLEFANANNLVDL 218

  Fly   394 ARMPKLEQLNLRSCDNI-SDIGMAYLTEGGSGINSLDVSFCD--KISDQALTHIAQGLYRLRSLS 455
            .::..|:.|::....|: :...:....|.|..:..|.|..|.  .|.::....:...|..|:.::
Worm   219 FQLTNLKVLDMSKSKNLETSKNVLRFVECGMNLPELRVLDCSGTDIDEELFAKLLSFLPNLQQIA 283

  Fly   456 LNQCQI------TDHGMLKIAKALHELENLNIGQCSRITDKGLQ-------TLAEDLTNLKTIDL 507
            |..||:      |:..:|..|......:.||.....:.:|..::       .|.|..|..|..|:
Worm   284 LMDCQLKHAVFSTEIRVLNSATLETSFQTLNYYSKLKKSDSVMKCFQDIFFLLKEYYTQNKEYDI 348

  Fly   508 YGC 510
            .||
Worm   349 AGC 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689
		AMN1	<226..>334	CDD:187754	26/112 (23%)
		leucine-rich repeat	236..256	CDD:275381	2/4 (50%)
		leucine-rich repeat	263..288	CDD:275381	5/27 (19%)
		leucine-rich repeat	289..314	CDD:275381	7/38 (18%)
		leucine-rich repeat	315..347	CDD:275381	10/32 (31%)
		AMN1	347..524	CDD:187754	37/201 (18%)
		leucine-rich repeat	348..373	CDD:275381	7/45 (16%)
		leucine-rich repeat	374..398	CDD:275381	3/23 (13%)
		leucine-rich repeat	399..424	CDD:275381	5/25 (20%)
		leucine-rich repeat	425..450	CDD:275381	5/26 (19%)
		leucine-rich repeat	451..475	CDD:275381	7/29 (24%)
		leucine-rich repeat	476..501	CDD:275381	5/31 (16%)
K05C4.9	NP_001362175.1	leucine-rich repeat	126..151	CDD:275381	10/32 (31%)
		leucine-rich repeat	152..176	CDD:275381	5/23 (22%)
		leucine-rich repeat	177..198	CDD:275378	2/20 (10%)
		leucine-rich repeat	199..223	CDD:275378	3/23 (13%)
		leucine-rich repeat	224..253	CDD:275378	5/28 (18%)
		leucine-rich repeat	254..278	CDD:275378	5/23 (22%)
		leucine-rich repeat	279..290	CDD:275378	4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162696
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930