DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and H24K24.2

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001300124.1	Gene:	H24K24.2 / 186774	WormBaseID:	WBGene00019239	Length:	473	Species:	Caenorhabditis elegans

Alignment Length:	355	Identity:	83/355 - (23%)
Similarity:	135/355 - (38%)	Gaps:	104/355 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 FNCLVKRGIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDL-- 268
            ||.||:         .|.|:..|.:..  .|..|....| ..|....||.|.     ||.:||
Worm    22 FNMLVR---------PLDRTASDKMFS--ELMKLKFGLC-EEALTRFGHFFC-----LKKVDLFN 69

  Fly   269 -SLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLN-------LRSCWH 325
             .:.|::.:      |...:|||:|.||.           :.|..:..:.:|       |.|..:
Worm    70 YHVSKELVE------AIRCQNLESLSLGN-----------LDWVKRGRRFMNGYDIVRFLESFLN 117

  Fly   326 ISDQGIGHLAGFSRET-------AEGNLQLEYLGLQDC----QRLSDEALGHIAQGLTSLKSINL 379
            ...:.:.|....:.|:       |:.|..|..|   .|    .:::|:...|:..|.::|:.:::
Worm   118 EESRNVLHSLEITMESPFAKEWPAKINNMLPAL---KCFAINGQVNDDEFSHLCIGFSNLRVLDI 179

  Fly   380 SFCVSVTDSGLKHLARMPKLEQLNLRSCDNI-----SD-IGMAYLTEGGSGINSLDVSFCDKISD 438
            |      ::.:::|:.|..|..|.:.|..|:     || |.:..||:    :..|||| .||  .
Worm   180 S------NTNIRNLSGMKMLVNLQILSMRNLDINQTSDLIELFSLTK----LTVLDVS-QDK--Q 231

  Fly   439 QALTHIAQGLYRLRSLSLN----QCQITDHGMLKIAKAL--------H------ELENLN----- 480
            .:.|.|.......|.:.|:    .|..||... :.||.|        |      :|:|.:
Worm   232 NSGTKIISTYLECRKILLDLKFIDCSRTDINR-EFAKTLLSSHPSIVHVSAIGCDLKNFSKCGTR 295

  Fly   481 IGQCSRITDKGLQTLAEDLTNLKTIDLYGC 510
            |..|:.|  :.|.....|.||||. :|..|
Worm   296 IFYCTSI--ESLFRSLIDFTNLKN-ELATC 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689
		AMN1	<226..>334	CDD:187754	24/117 (21%)
		leucine-rich repeat	236..256	CDD:275381	6/19 (32%)
		leucine-rich repeat	263..288	CDD:275381	6/27 (22%)
		leucine-rich repeat	289..314	CDD:275381	6/24 (25%)
		leucine-rich repeat	315..347	CDD:275381	7/45 (16%)
		AMN1	347..524	CDD:187754	49/197 (25%)
		leucine-rich repeat	348..373	CDD:275381	6/28 (21%)
		leucine-rich repeat	374..398	CDD:275381	4/23 (17%)
		leucine-rich repeat	399..424	CDD:275381	9/30 (30%)
		leucine-rich repeat	425..450	CDD:275381	8/24 (33%)
		leucine-rich repeat	451..475	CDD:275381	9/41 (22%)
		leucine-rich repeat	476..501	CDD:275381	7/29 (24%)
H24K24.2	NP_001300124.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162691
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930