DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and F53G2.1

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_494284.1	Gene:	F53G2.1 / 186184	WormBaseID:	WBGene00018766	Length:	714	Species:	Caenorhabditis elegans

Alignment Length:	454	Identity:	96/454 - (21%)
Similarity:	180/454 - (39%)	Gaps:	138/454 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 QVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGIKKVQILSLR---------RSLKDL 229
            ::.|..::.:|..||:: :::|     ||..::|.|:::..:....:||:         .|.|:.
Worm    10 KIATYIQNGSYDNSVYR-LDSK-----SSNKIYNLLLEKKNELTDRISLQVAAKFNLSEISFKNF 68

  Fly   230 --------VLGVPALTSLNLSGCFNVA--------DMNLGHAFSVDL-----PNLKTLDLSLCKQ 273
                    :|....|.||.|....|:|        .:|:.:..|..|     .||:|||||..::
Worm    69 PNSTIYVEILQKSCLKSLCLGNLKNIASFFEDDQKSINICYLLSYYLNEDSRRNLQTLDLSGKEE 133

  Fly   274 ITDTSLGRIAQHLRNLETLELGG-----------CCN--------ITNTGLLLIAWGLKKLKHL- 318
            .:.....:|.....:|.||.:.|           |.|        |::|.:.|: :|:..|.||
Worm   134 FSTGWTVKIGHMFPSLTTLSIRGRTLYKKEFLVVCQNFPKLISLDISDTNVQLL-FGISYLIHLR 197

  Fly   319 -----NLRSCWHISDQGIGHLAG-----FSRETAEGNLQL--EYLGLQDCQRLSDEALGHIAQGL 371
                 ||....|.....:.||:|     .||:....:::.  :|:   ||           ..||
Worm   198 ELTMQNLTFLSHFVWLDLFHLSGLEFLDISRDKLNKDMKTVRQYV---DC-----------GMGL 248

  Fly   372 TSLKSINLSFCVSVTDS-----GLKHLARMPKLEQL----NLRSCDNISDIGMAYLTEG--GSGI 425
            ::|:.::.| ...:.|.     .|.|    |||:|:    ::.....|...||..|...  ||.:
Worm   249 SNLRFLDCS-GTDIDDQLVQCLQLSH----PKLKQICVFDSVLQRSTIQSAGMMTLNTATLGSSL 308

  Fly   426 NSLDVSFCDKISDQAL--------THIAQGLYRLRSLSLNQCQITDHGMLKIAKALHELENLNIG 482
            |.|:. |..:..:.|:        ||:    |..:...||.....:..:    :|::...:.|:|
Worm   309 NCLNY-FVARRKEYAVWKCLKEINTHV----YNTKDDELNHTNFINCTL----RAMNTFSSKNVG 364

  Fly   483 QCSRITDKGLQTLAEDLTNLKTIDL------YGCTQLSSKGIDIIMKLPKLQKL-----NLGLW 535
                  |:|::.|.: ::..:|:.:      ....:||    :.|:.||.|..|     ::.:|
Worm   365 ------DEGIRCLVQ-ISMQETMKMPILERSLALKRLS----NFIVDLPSLDSLDRLGFHVAVW 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	4/15 (27%)
		AMN1	<226..>334	CDD:187754	35/153 (23%)
		leucine-rich repeat	236..256	CDD:275381	7/27 (26%)
		leucine-rich repeat	263..288	CDD:275381	7/24 (29%)
		leucine-rich repeat	289..314	CDD:275381	10/43 (23%)
		leucine-rich repeat	315..347	CDD:275381	11/42 (26%)
		AMN1	347..524	CDD:187754	39/203 (19%)
		leucine-rich repeat	348..373	CDD:275381	5/26 (19%)
		leucine-rich repeat	374..398	CDD:275381	5/28 (18%)
		leucine-rich repeat	399..424	CDD:275381	7/30 (23%)
		leucine-rich repeat	425..450	CDD:275381	6/32 (19%)
		leucine-rich repeat	451..475	CDD:275381	3/23 (13%)
		leucine-rich repeat	476..501	CDD:275381	5/24 (21%)
F53G2.1	NP_494284.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162688
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930