DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and gadr-3

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_498378.2	Gene:	gadr-3 / 185933	WormBaseID:	WBGene00018561	Length:	710	Species:	Caenorhabditis elegans

Alignment Length:	462	Identity:	93/462 - (20%)
Similarity:	178/462 - (38%)	Gaps:	147/462 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 CTAWRDAAY--AKSVWKGVEAKLHLKRSSPSLFNCLVK--RGI---------KKVQILSL----- 222
            |.|....|:  ...:::.::.||..| ||..:::.|:|  ||:         :::::.::
Worm     7 CIATEKVAHYINDGIYRNLKYKLDSK-SSDQVYSKLLKISRGLIHEYNHEIGQRLELRNVDYGKF 70

  Fly   223 ---RRSLKDLVLGVPALTSLNLSGCFNVADMN-LGHAFSVDLPNLKTLDL-SLCKQITDTSLGRI 282
               |.::  :||....|.||      .:.|:: :|:.:. ||.:..|:|: .|.|.|.:.
Worm    71 KIDRNTV--MVLKKHCLESL------GIGDLDYIGYYYR-DLIDDNTIDIFELLKAILNN----- 121

  Fly   283 AQHLRNLETLELGGCCNIT-----NTGLLLIAWGLKKL----KHL-------------NLRSCWH 325
             :..|||..|::.|....:     |.|.:|..  |:.|    :||             || :...
Worm   122 -ETRRNLHYLDIKGSHAFSKKWTKNIGTILPV--LRSLIICGRHLQSDDFQQLCESIPNL-TYLD 182

  Fly   326 ISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGL 390
            ||:..:.:::|.|......:|.:..:.|:..::..|      ...||.|:.:::|..:...|:.:
Worm   183 ISETNVPNISGISSLKNLESLIMRSVELECFEQFVD------LFNLTGLRILDVSRSMYKHDTKI 241

  Fly   391 --KHLARMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKI--SDQALTHIAQGLYRL 451
              :::.....|::|....|             .|:.||.   :..::|  |...|..:|.....:
Worm   242 INQYVQSNKVLKELRFLEC-------------SGTDINK---NLLEQILNSHDNLQQVAAINCHI 290

  Fly   452 RSLS-------LNQCQITDH--------GMLKIAKALHELENL---------------NIGQCSR 486
            ||||       ||...:|..        |:.:|:.....|||:               :..:|.:
Worm   291 RSLSLHHEVFLLNTATLTSSLKSLTHYLGVHRISSVERVLENMLHLFPKYDPDLDNRFDFSECVK 355

  Fly   487 I---------TDKGLQ---TLA-------EDLTNLKTIDLYGCTQLSSKGIDIIMKLPKL----Q 528
            |         :..|:|   ||.       :| ...:..|||   ||..|.:|.:....:|    :
Worm   356 IIINSALKIESSLGIQGYGTLCLWHIARNQD-ARFQPFDLY---QLVCKLLDGVYNNGRLFIATK 416

  Fly   529 KLNLGLW 535
            ..|:.||
Worm   417 DFNISLW 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	3/15 (20%)
		AMN1	<226..>334	CDD:187754	30/131 (23%)
		leucine-rich repeat	236..256	CDD:275381	5/20 (25%)
		leucine-rich repeat	263..288	CDD:275381	5/25 (20%)
		leucine-rich repeat	289..314	CDD:275381	7/29 (24%)
		leucine-rich repeat	315..347	CDD:275381	9/48 (19%)
		AMN1	347..524	CDD:187754	43/229 (19%)
		leucine-rich repeat	348..373	CDD:275381	3/24 (13%)
		leucine-rich repeat	374..398	CDD:275381	3/25 (12%)
		leucine-rich repeat	399..424	CDD:275381	4/24 (17%)
		leucine-rich repeat	425..450	CDD:275381	6/26 (23%)
		leucine-rich repeat	451..475	CDD:275381	9/38 (24%)
		leucine-rich repeat	476..501	CDD:275381	10/58 (17%)
gadr-3	NP_498378.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162695
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930