DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and C48D1.1

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001040928.2	Gene:	C48D1.1 / 178271	WormBaseID:	WBGene00008177	Length:	632	Species:	Caenorhabditis elegans

Alignment Length:	379	Identity:	86/379 - (22%)
Similarity:	141/379 - (37%)	Gaps:	126/379 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 LHLKRSSPSLFNCLVKRGIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLG----HAF 256
            ||:::...     |:||...|:..:            :|:||.|.:|      |:::.    :..
Worm   127 LHIEKDQK-----LMKRWTAKIGNM------------LPSLTHLTMS------DVHINEDDFYQL 168

  Fly   257 SVDLPNLKTLDLSLCKQITDTSLGRIA--QHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHL- 318
            ..:..||::||:|      .|::..||  ..|:.||.|.|......|.|.|.    .|..||||
Worm   169 FGNFSNLRSLDIS------GTNILNIAGISRLKQLEVLALRDFSIATYTELK----DLFNLKHLR 223

  Fly   319 ---------NLRSCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSL 374
                     ||.|..:|.:|           ..|..::|..|...||.|             |||
Worm   224 VLDVSQTRFNLHSRNNIVEQ-----------FTECKMELPELRFMDCTR-------------TSL 264

  Fly   375 KSINLSFCVSVTDSGLKHLARMPKLEQLNLRSCDNISDIGMAYLTEGGSG----INSLDVSFCDK 435
             |.::..|:..|              |.||:....|       :||..:.    :..|:.::..|
Worm   265 -SGDILECLLKT--------------QRNLQLVTTI-------MTEAETSQYNDVRVLNTAYFHK 307

  Fly   436 ISDQALTHIAQGLYRLRSLSLNQCQITDHGMLKIAKALHELENLNIGQCSRITDKGLQT---LAE 497
             |.|||.:.   |...:......|.    ..::|:.:...|:||||..|.:...|.:||   ::.
Worm   308 -SVQALVYC---LTARKEFDSGYCM----KAIRISISEDNLQNLNIPSCIKTIVKSMQTFDSISV 364

  Fly   498 DLTNLKTIDLYG---CTQLSSKGIDIIMK-------LPKLQ------KLNLGLW 535
            ....||.:.::|   ..||.|.|:.::::       |.|..      |:|:..|
Worm   365 TQNGLKCLIIFGMLYSNQLCSNGVTLLVEALMSFVYLYKRMISEAYVKVNISYW 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689
		AMN1	<226..>334	CDD:187754	32/123 (26%)
		leucine-rich repeat	236..256	CDD:275381	5/23 (22%)
		leucine-rich repeat	263..288	CDD:275381	8/26 (31%)
		leucine-rich repeat	289..314	CDD:275381	8/24 (33%)
		leucine-rich repeat	315..347	CDD:275381	10/41 (24%)
		AMN1	347..524	CDD:187754	42/193 (22%)
		leucine-rich repeat	348..373	CDD:275381	5/24 (21%)
		leucine-rich repeat	374..398	CDD:275381	4/23 (17%)
		leucine-rich repeat	399..424	CDD:275381	6/24 (25%)
		leucine-rich repeat	425..450	CDD:275381	7/24 (29%)
		leucine-rich repeat	451..475	CDD:275381	2/23 (9%)
		leucine-rich repeat	476..501	CDD:275381	9/27 (33%)
C48D1.1	NP_001040928.2	leucine-rich repeat	124..149	CDD:275380	6/38 (16%)
		leucine-rich repeat	150..174	CDD:275380	5/29 (17%)
		leucine-rich repeat	175..196	CDD:275380	8/26 (31%)
		leucine-rich repeat	197..221	CDD:275380	9/27 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162693
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930