DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and T01E8.1

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001364580.1	Gene:	T01E8.1 / 174584	WormBaseID:	WBGene00011331	Length:	516	Species:	Caenorhabditis elegans

Alignment Length:	406	Identity:	77/406 - (18%)
Similarity:	149/406 - (36%)	Gaps:	136/406 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 NLKTLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHI 326
            |:.:|...|..::||..|.::..:.:.:|.:.|..|.|:||.|...:..|...|:.|.||:...:
Worm    60 NIPSLTFYLSAELTDEMLNQLTTNNKYVEKITLVDCPNVTNLGAQAVTTGQILLRQLELRAMHQL 124

  Fly   327 SDQGIGH----------LAGFSRETAEG-------NLQLEYLGLQDCQRLSDEALGHIAQGL-TS 373
            :||.:.:          |:|..:.|::|       |..:..|.|..|:.|.|:.|..||..: ..
Worm   125 TDQCLENVYSPFLYSVDLSGCGKITSQGIRTLLIKNPTIGCLYLNHCRSLDDQVLYDIAHYVGDR 189

  Fly   374 LKSINLSFCVSVTD--SGLKHL-ARMPKLEQLNLRSC--DNISDI--GMAYLTEGGSGINSLDV- 430
            |..:.|.|..|:.|  :.|.:| ::.|.|.||:|...  :|:.|:  .:.::.:||: :.:||:
Worm   190 LHVLELDFPTSLADPAAALHYLSSQCPNLSQLSLARFFHENLEDVENNVQFVIDGGN-LKTLDLY 253

  Fly   431 -------------------------------------SFCDKIS-------------DQA----- 440
                                                 .|.:.|:             |.|
Worm   254 GNYFSLMPQLPPTVQSIRLSVSGDEDSQQLLSTLMDQPFLNSINLIVSVREANIQAVDNANHLLC 318

  Fly   441 ----------------------------------LTHIA--------------------QGLYRL 451
                                              |||::                    ....:|
Worm   319 AIIPLLGHKITKLQISVPRLFDEPLKLVTEYLPNLTHLSLEINHLNTNILQKYFAGGSKSNASKL 383

  Fly   452 RSLSLNQCQITDHGMLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSK 516
            :.|.:.:.::|...:..||:....|.:|.....|.:.|:.|..|..:...|:.:::.||..:|.|
Worm   384 KCLKICRMRMTYRVLFAIARGARNLTDLETSHMSSVDDRFLCLLGGNCRQLRCLNINGCRMVSDK 448

  Fly   517 GIDIIMKLPKLQKLNL 532
            |:.::.|...|:::.:
Worm   449 GLAVLAKRCPLREVRI 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689
		AMN1	<226..>334	CDD:187754	20/81 (25%)
		leucine-rich repeat	236..256	CDD:275381
		leucine-rich repeat	263..288	CDD:275381	5/24 (21%)
		leucine-rich repeat	289..314	CDD:275381	8/24 (33%)
		leucine-rich repeat	315..347	CDD:275381	11/48 (23%)
		AMN1	347..524	CDD:187754	50/294 (17%)
		leucine-rich repeat	348..373	CDD:275381	8/25 (32%)
		leucine-rich repeat	374..398	CDD:275381	7/26 (27%)
		leucine-rich repeat	399..424	CDD:275381	8/28 (29%)
		leucine-rich repeat	425..450	CDD:275381	9/134 (7%)
		leucine-rich repeat	451..475	CDD:275381	5/23 (22%)
		leucine-rich repeat	476..501	CDD:275381	6/24 (25%)
T01E8.1	NP_001364580.1	leucine-rich repeat	190..217	CDD:275381	7/26 (27%)
		leucine-rich repeat	328..352	CDD:275381	0/23 (0%)
		leucine-rich repeat	353..382	CDD:275381	3/28 (11%)
		leucine-rich repeat	383..407	CDD:275381	5/23 (22%)
		leucine-rich repeat	408..433	CDD:275381	6/24 (25%)
		AMN1	<430..>512	CDD:187754	8/35 (23%)
		leucine-rich repeat	434..452	CDD:275381	6/17 (35%)
		leucine-rich repeat	459..483	CDD:275381	1/6 (17%)
		leucine-rich repeat	484..510	CDD:275381
		leucine-rich repeat	61..86	CDD:275381	5/24 (21%)
		AMN1	<69..203	CDD:187754	34/133 (26%)
		leucine-rich repeat	87..112	CDD:275381	8/24 (33%)
		leucine-rich repeat	113..136	CDD:275381	6/22 (27%)
		leucine-rich repeat	137..162	CDD:275381	5/24 (21%)
		leucine-rich repeat	163..189	CDD:275381	8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820