DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and gadr-4

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001317764.1	Gene:	gadr-4 / 173745	WormBaseID:	WBGene00021053	Length:	797	Species:	Caenorhabditis elegans

Alignment Length:	434	Identity:	91/434 - (20%)
Similarity:	164/434 - (37%)	Gaps:	115/434 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 LFPELLEQIFEHLPVRD--LGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGI 214
            |:..:|: |.:.:|::.  ||:...:...::..:...|:...:..|..|..:|.:|...|   .|
Worm   158 LYRGILD-ILKAMPIQSIKLGKLDLIENDYKQRSDKSSIDISMLIKSALSDNSRALLQHL---DI 218

  Fly   215 KKVQILSLRRSLKDLVLGVPALTSLNLSG-CFNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTS 278
            :..::||:....| :.|.:|:|.||::.| .|.|.:..                 .||:...
Worm   219 EGREVLSINWPRK-IGLLLPSLASLHVKGRSFFVFEFT-----------------QLCRSFP--- 262

  Fly   279 LGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAE 343
                     ||.:|.:.| .||.|..      |:..||.|.:.|...:..:...||....
Worm   263 ---------NLISLNISG-TNIKNLN------GISALKRLEVLSMQFLEIETTEHLINLF----- 306

  Fly   344 GNL-QLEYLGLQDCQRLSDEALGHI----AQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLN 403
             || .|::|.:.|........:.|:    .:||.:||.::.:......|...|.|...||||.::
Worm   307 -NLSNLKFLDISDIPEYDSCIIVHLYVECGKGLPNLKFMDCTATDINNDLLEKILISHPKLETIS 370

  Fly   404 --LRSCDNISDIGMAYLTEGG--SGINSLDVSFCDKISDQALTHIAQG-LYRLRSL--------- 454
              :.:...:||.|:..|....  |.:.||  ..|.:::   |.::|:. .|.:|.|
Worm   371 AIVTNLHRVSDSGVCVLQTDAIDSAVTSL--IQCSRLN---LHYLAEKCFYEIRDLLESGQHFNA 430

  Fly   455 -----------SLNQCQI-TDHG---MLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKT 504
                       ..:.|.| ..||   ::::|:  |:.:.|.:.:.|.:.|    ||...:..|..
Worm   431 SEFLRKIINLIETSSCPIRKKHGISYLIELAE--HQCQKLTLLEVSILLD----TLLNQVLELPE 489

  Fly   505 IDLYGCTQLSSKGIDIIMKLPKLQKLNLGLW-----LVRXCVHH 543
            ||.|               |.:.:..|:.:|     |.....||
Worm   490 IDDY---------------LSENKSYNISMWCALDNLTNSENHH 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	7/39 (18%)
		AMN1	<226..>334	CDD:187754	23/108 (21%)
		leucine-rich repeat	236..256	CDD:275381	6/20 (30%)
		leucine-rich repeat	263..288	CDD:275381	2/24 (8%)
		leucine-rich repeat	289..314	CDD:275381	7/24 (29%)
		leucine-rich repeat	315..347	CDD:275381	8/32 (25%)
		AMN1	347..524	CDD:187754	43/209 (21%)
		leucine-rich repeat	348..373	CDD:275381	6/28 (21%)
		leucine-rich repeat	374..398	CDD:275381	5/23 (22%)
		leucine-rich repeat	399..424	CDD:275381	6/28 (21%)
		leucine-rich repeat	425..450	CDD:275381	5/25 (20%)
		leucine-rich repeat	451..475	CDD:275381	7/47 (15%)
		leucine-rich repeat	476..501	CDD:275381	5/24 (21%)
gadr-4	NP_001317764.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162690
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940