DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and FBXL16

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_699181.2	Gene:	FBXL16 / 146330	HGNCID:	14150	Length:	479	Species:	Homo sapiens

Alignment Length:	503	Identity:	134/503 - (26%)
Similarity:	220/503 - (43%)	Gaps:	102/503 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 ELPGLTR-TGATTTHHHLLRFTPYALHHR-----PPHHQLQTLPP---ALYLQHAAAAAA----A 113
            :|||... .||.:    :.:.|| |..:|     ||    .||||   |..|..||.|..    |
Human    22 KLPGQPNGLGAAS----ITKGTP-ATKNRPCQPPPP----PTLPPPSLAAPLSRAALAGGPCTPA 77

  Fly   114 AAAAAAHAQHHHHHHHHLPHRPASPESPPPVEGTHISNLFPELLEQIFEHLPVRDLGRAAQVCTA 178
            ...|:|.|             |..|...||:....      ::|..:|.:....:....||||.|
Human    78 GGPASALA-------------PGHPAERPPLATDE------KILNGLFWYFSACEKCVLAQVCKA 123

  Fly   179 WRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGIKKVQILSLRRSLKDLVLGVPALTSLNLSG 243
            ||...|....|.|:...||.|    .|:|.| ..|.|:.                     :||.|
Human   124 WRRVLYQPKFWAGLTPVLHAK----ELYNVL-PGGEKEF---------------------VNLQG 162

  Fly   244 ---------CF-NVADMNLGH---AFSVDLPNLKTLDLSLCKQITDTSLGRIAQHLRNLETLELG 295
                     |. .|:|:::..   .:::....:|.:.|.. ..|||..|..:.:.::.:..|||.
Human   163 FAARGFEGFCLVGVSDLDICEFIDNYALSKKGVKAMSLKR-STITDAGLEVMLEQMQGVVRLELS 226

  Fly   296 GCCNITNTGLLLIAWG--LKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQR 358
            ||.:.|..||    |.  ..::..|::..|.:::|..|..::......||.:||        ...
Human   227 GCNDFTEAGL----WSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQ--------AYH 279

  Fly   359 LSDEALGHIA--QGLTSLKSINLSFCVSVTDSGLKHLAR-MPKLEQLNLRSCDNISDIGMAYLTE 420
            ::|.||.:..  || .|..::.|..|..:|:.|:.::.. :|.|..|:|..|..::|.|:..:.|
Human   280 VTDTALAYFTARQG-HSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAE 343

  Fly   421 GGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQC-QITDHGMLKIAKALHELENLNIGQC 484
            ....:.|||:|:|.:|:|.||.::|..|:||..|.|::| :|||.| |.....:..|.:|.:..|
Human   344 NLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTG-LSYLSTMSSLRSLYLRWC 407

  Fly   485 SRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGIDIIMKLPKLQKLNL 532
            .::.|.||:.|.. |.:|:.:.|.||..|::.|:..:::|.:|::|.|
Human   408 CQVQDFGLKHLLA-LGSLRLLSLAGCPLLTTTGLSGLVQLQELEELEL 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	10/40 (25%)
		AMN1	<226..>334	CDD:187754	25/122 (20%)
		leucine-rich repeat	236..256	CDD:275381	6/32 (19%)
		leucine-rich repeat	263..288	CDD:275381	6/24 (25%)
		leucine-rich repeat	289..314	CDD:275381	9/26 (35%)
		leucine-rich repeat	315..347	CDD:275381	6/31 (19%)
		AMN1	347..524	CDD:187754	54/180 (30%)
		leucine-rich repeat	348..373	CDD:275381	5/26 (19%)
		leucine-rich repeat	374..398	CDD:275381	4/24 (17%)
		leucine-rich repeat	399..424	CDD:275381	7/24 (29%)
		leucine-rich repeat	425..450	CDD:275381	11/24 (46%)
		leucine-rich repeat	451..475	CDD:275381	9/24 (38%)
		leucine-rich repeat	476..501	CDD:275381	8/24 (33%)
FBXL16	NP_699181.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		15/48 (31%)
		AMN1	201..413	CDD:332986	63/226 (28%)
		leucine-rich repeat	220..243	CDD:275381	9/26 (35%)
		leucine-rich repeat	244..269	CDD:275381	4/24 (17%)
		LRR 1	244..266		4/21 (19%)
		LRR 2	267..290		7/30 (23%)
		leucine-rich repeat	270..295	CDD:275381	9/33 (27%)
		leucine-rich repeat	296..321	CDD:275381	4/24 (17%)
		LRR 3	319..343		7/23 (30%)
		leucine-rich repeat	322..347	CDD:275381	7/24 (29%)
		LRR 4	345..369		9/23 (39%)
		leucine-rich repeat	348..373	CDD:275381	11/24 (46%)
		LRR 5	371..395		11/24 (46%)
		leucine-rich repeat	374..398	CDD:275381	9/24 (38%)
		LRR 6	396..420		7/23 (30%)
		LRR 7	446..470		4/9 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820