DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and FBXL14

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_689654.1	Gene:	FBXL14 / 144699	HGNCID:	28624	Length:	418	Species:	Homo sapiens

Alignment Length:	413	Identity:	249/413 - (60%)
Similarity:	316/413 - (76%)	Gaps:	10/413 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 THISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVK 211
            ||||.||||||..||.:|.|||.|||||||||||||||.||||:||||||||:|::||||..|..
Human     3 THISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQA 67

  Fly   212 RGIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITD 276
            |||::||||||||||..::.|:..:.|||||||:|:.|..|||||..::.:|:.|:|||||||||
Human    68 RGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITD 132

  Fly   277 TSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRET 341
            :|||||||:|:.||.||||||.||||||||||||||::||.||||||.|:||.|||||||.:|..
Human   133 SSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSA 197

  Fly   342 AEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLNLRS 406
            |||.|.||.|.|||||:|:|.:|.||::|||.|:.:|||||..::|:||.||:.|..|..|||||
Human   198 AEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRS 262

  Fly   407 CDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQITDHGMLKIAK 471
            ||||||.|:.:|..|...::.||||||||:.||:|.:|||||..|:||||..|.|:|.|:.::.:
Human   263 CDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINRMVR 327

  Fly   472 ALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGIDIIMKLPKLQKLNLGLWL 536
            .:|.|..||||||.|||||||:.:||.|:.|..|||||||:::.:|::.|.:||.|:.||||||.
Human   328 QMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQLPCLKVLNLGLWQ 392

  Fly   537 VRXCVHHDCNACAAKEAARGSYN 559
            :.           :::.|||.::
Human   393 MTD----------SEKEARGDFS 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	32/40 (80%)
		AMN1	<226..>334	CDD:187754	71/107 (66%)
		leucine-rich repeat	236..256	CDD:275381	12/19 (63%)
		leucine-rich repeat	263..288	CDD:275381	19/24 (79%)
		leucine-rich repeat	289..314	CDD:275381	22/24 (92%)
		leucine-rich repeat	315..347	CDD:275381	22/31 (71%)
		AMN1	347..524	CDD:187754	96/176 (55%)
		leucine-rich repeat	348..373	CDD:275381	15/24 (63%)
		leucine-rich repeat	374..398	CDD:275381	12/23 (52%)
		leucine-rich repeat	399..424	CDD:275381	15/24 (63%)
		leucine-rich repeat	425..450	CDD:275381	16/24 (67%)
		leucine-rich repeat	451..475	CDD:275381	9/23 (39%)
		leucine-rich repeat	476..501	CDD:275381	17/24 (71%)
FBXL14	NP_689654.1	Required for down-regulation of SNAI1	2..48		35/44 (80%)
		F-box-like	5..46	CDD:403981	32/40 (80%)
		AMN1	90..296	CDD:187754	130/205 (63%)
		leucine-rich repeat	92..118	CDD:275381	14/25 (56%)
		leucine-rich repeat	119..142	CDD:275381	18/22 (82%)
		LRR 1	144..163		15/18 (83%)
		leucine-rich repeat	145..170	CDD:275381	22/24 (92%)
		LRR 2	170..191		15/20 (75%)
		leucine-rich repeat	171..203	CDD:275381	22/31 (71%)
		LRR 3	203..225		13/21 (62%)
		leucine-rich repeat	204..229	CDD:275381	15/24 (63%)
		AMN1	228..401	CDD:187754	90/182 (49%)
		LRR 4	229..250		10/20 (50%)
		leucine-rich repeat	230..254	CDD:275381	12/23 (52%)
		LRR 5	254..275		13/20 (65%)
		leucine-rich repeat	255..280	CDD:275381	15/24 (63%)
		leucine-rich repeat	281..306	CDD:275381	16/24 (67%)
		leucine-rich repeat	307..331	CDD:275381	9/23 (39%)
		leucine-rich repeat	332..357	CDD:275381	17/24 (71%)
		leucine-rich repeat	358..382	CDD:275381	11/23 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144542
Domainoid	1	1.000	87	1.000	Domainoid score	I8037
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15271
Inparanoid	1	1.050	495	1.000	Inparanoid score	I1404
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59093
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	1	1.000	-	-		FOG0008216
OrthoInspector	1	1.000	-	-		oto89616
orthoMCL	1	0.900	-	-		OOG6_101394
Panther	1	1.100	-	-	LDO	PTHR13318
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5805
SonicParanoid	1	1.000	-	-		X6186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800