DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and AgaP_AGAP001895

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_321169.5	Gene:	AgaP_AGAP001895 / 1281229	VectorBaseID:	AGAP001895	Length:	1352	Species:	Anopheles gambiae

Alignment Length:	626	Identity:	134/626 - (21%)
Similarity:	201/626 - (32%)	Gaps:	248/626 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NTELLPFH---HQTIAVLNNLNSHCGGSGSNGA--ATSGGAAIGGAGAGG--------------- 48
            ||:..|.|   .|..:.:..::.....|.::.|  ...||:..||||:||
Mosquito   779 NTDYRPRHFRARQKSSDIRRMSCSSDASSAHNAEFGRIGGSGHGGAGSGGEGSMNSTGDGMMAGA 843

  Fly    49 ------APSWAMDELYQ-----QTELPG------------------------LTRTGATTTHHHL 78
                  ||.:..|.||.     ...:.|                        ...:|.....||.
Mosquito   844 NVSAPRAPRFQDDMLYDFAVSGSAVIVGSKGGNILFERKPKIKDEDMSSGSEYDASGVGKKMHHS 908

  Fly    79 LRFTPYA-----------------LHHRP------PHHQLQTLPPALYLQHAAAAAAAAAAAA-- 118
            |..:|.|                 |.|.|      .||....:.....:|...|.|::.||:|
Mosquito   909 LNSSPGAGTAMGGGSMKVEVKDEPLDHHPNHGYPANHHATSVIKDGREMQREQALASSCAASADG 973

  Fly   119 ------------AHAQHHH----------------------------------HHHHH------- 130
                        |...|||                                  |..|.
Mosquito   974 VAVKRRKSDEGGAINTHHHSGGTGTGAADGNEAKNSHGGSLPRKKSSQRMQLAHQIHSTSTKPMK 1038

  Fly   131 ---LPHRPASPESPPPVEGTHISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGV 192
               .|.||||....|.:..:....|....|..:|.:||...|.....||..|.:.|...|:||.:
Mosquito  1039 KPLYPIRPASVAHTPTMSLSGNYALDAPCLLAVFRYLPPETLVTCTMVCKTWANIAVDPSLWKRM 1103

  Fly   193 ---EAKLHLKRSSPSLFNCLVKR----------GIKKVQILSLRRSLKDLVLGVPALTSLNLSGC 244
               |.||     ||:|.:.:|:|          |:.|       |.:..|:..:|.|.:|:|.|.
Mosquito  1104 NCAEYKL-----SPNLLSAIVRRQPEHLIMDWIGLGK-------RQVTWLISRIPGLKNLSLQGT 1156

  Fly   245 FNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTSLGRI--------------AQHLRNLETLELG 295
            ...|.:.|   .:...|.|:.||||....:.|.::..|              ...||||:.|::.
Mosquito  1157 HIQAVLGL---HTCMCPPLQVLDLSFIAGLNDFAIREILSPPKDSRPGLADSKSRLRNLKMLKVA 1218

  Fly   296 GCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLS 360
            | .:|::..|..|..||..|.||:|.|                                 |||::
Mosquito  1219 G-ADISDVALRYITQGLPNLTHLDLSS---------------------------------CQRIT 1249

  Fly   361 DEALGHIAQGLTSLKS---INLSFCVSVTDSGLKHLARMPKLEQLNLRSCDNISDIGMAYLTEGG 422
            |.|:..|.....::|:   ::||.|..:|:..|.|||:           ||
Mosquito  1250 DAAIAQIGTSPAAIKTLVELDLSCCKLITELSLDHLAK-----------CD-------------- 1289

  Fly   423 SGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQITD 463
             .:..||:|...::|.|::...|       |:|.|..|:.|
Mosquito  1290 -ALTRLDLSHVPQVSTQSMIKFA-------SISKNDLQLHD 1322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	11/40 (28%)
		AMN1	<226..>334	CDD:187754	32/121 (26%)
		leucine-rich repeat	236..256	CDD:275381	6/19 (32%)
		leucine-rich repeat	263..288	CDD:275381	8/38 (21%)
		leucine-rich repeat	289..314	CDD:275381	8/24 (33%)
		leucine-rich repeat	315..347	CDD:275381	5/31 (16%)
		AMN1	347..524	CDD:187754	28/120 (23%)
		leucine-rich repeat	348..373	CDD:275381	6/24 (25%)
		leucine-rich repeat	374..398	CDD:275381	9/26 (35%)
		leucine-rich repeat	399..424	CDD:275381	2/24 (8%)
		leucine-rich repeat	425..450	CDD:275381	6/24 (25%)
		leucine-rich repeat	451..475	CDD:275381	5/13 (38%)
		leucine-rich repeat	476..501	CDD:275381
AgaP_AGAP001895	XP_321169.5	cupin_like	190..290	CDD:304367
		zf-CXXC	653..691	CDD:251032
		PHD_4	696..773	CDD:293471
		F-box-like	1068..1105	CDD:289689	12/36 (33%)
		leucine-rich repeat	1100..1123	CDD:275381	10/27 (37%)
		leucine-rich repeat	1124..1147	CDD:275381	4/29 (14%)
		AMN1	1146..>1312	CDD:187754	54/235 (23%)
		leucine-rich repeat	1172..1211	CDD:275381	8/38 (21%)
		leucine-rich repeat	1212..1236	CDD:275381	8/24 (33%)
		leucine-rich repeat	1237..1265	CDD:275381	11/60 (18%)
		leucine-rich repeat	1266..1290	CDD:275381	10/49 (20%)
		leucine-rich repeat	1291..1310	CDD:275381	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810