DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and AgaP_AGAP011911

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_320618.4	Gene:	AgaP_AGAP011911 / 1280753	VectorBaseID:	AGAP011911	Length:	517	Species:	Anopheles gambiae

Alignment Length:	478	Identity:	107/478 - (22%)
Similarity:	159/478 - (33%)	Gaps:	167/478 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 THISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGV---EAKLHLKR-------- 200
            |..|||...:||:||.||.:::...|:..|:.|..|.|...||...   :|.|...|
Mosquito    49 TQWSNLPDHILERIFSHLTIKERYYASLTCSGWYRAFYLPHVWSNFLVEDATLGRMRYNYYSGWQ 113

  Fly   201 ---SSPSLFNCLVK-----RGI------------KKVQILSLRRSLKDLVLGVP--------ALT 237
               ....|.:||:.     ||:            :.:.::|..........|.|        .:.
Mosquito   114 PVLDHARLQSCLLSVGHLIRGLDFRPQVSFNNMFQFMSLISWAMEQNARTAGCPREWVGCGSRIR 178

  Fly   238 SLN-LSGCFNVADMNLGHAFSVDLPNLKTLD-----------LSLC------KQITDTSLGRI-A 283
            ||| |..|      |:  |.|.|..::|...           |.||      ..:.|..|.|. |
Mosquito   179 SLNYLFPC------NM--AMSEDPESIKLFGTGGQLLAALKRLMLCLTNLHSLSLVDLFLERYEA 235

  Fly   284 QHLRNLETLELGGCC---------NITNTGLLLIAWGLKKLKHLNLR----SCWHISDQGIGHLA 335
            .||.: |.||  .||         |:||....::..||    .|||:    |..:|.|..:..||
Mosquito   236 NHLLD-EVLE--SCCLVLRRLCLVNVTNVHCPIMHIGL----FLNLQVLVVSPQNIDDDVLMLLA 293

  Fly   336 GFSRETAEGNLQLEY----LGLQDCQRLSDEALGHIAQGLTSLK----SINLSFCVSVTDSGL-- 390
            . |:......||..|    |.:..|.          |:...:::    .:.:..||..|.:.:
Mosquito   294 D-SKVKHLTLLQNRYTPPALAISPCS----------AKAWLTVRRDNPKLRVHLCVESTTNAVIL 347

  Fly   391 --------KHLARMPKL-----------------------EQLNLRSCDNISDIG---------M 415
                    ..:.:.||.                       |||...:.:.:.| |         :
Mosquito   348 LQPEAPVASMIYQTPKTMITSDQLVAAVDAYKYTLTVYGHEQLPATTAEAVGD-GEFQERPDSLL 411

  Fly   416 AYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQI------------TD--HGM 466
            ..|.....|:|:|.|..|  ||...:..||.....||.|.:|:.|:            ||  :|.
Mosquito   412 LLLARSCPGLNALMVREC--ISTATILLIATSAQNLRHLYINRAQVRLGCDWPRSPDWTDEFYGW 474

  Fly   467 LKIAKALHELENLNIGQCSRITD 489
            |:...|..|.....:   |||.|
Mosquito   475 LQSTAASIEATEQEV---SRILD 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	15/40 (38%)
		AMN1	<226..>334	CDD:187754	37/147 (25%)
		leucine-rich repeat	236..256	CDD:275381	6/20 (30%)
		leucine-rich repeat	263..288	CDD:275381	10/42 (24%)
		leucine-rich repeat	289..314	CDD:275381	10/33 (30%)
		leucine-rich repeat	315..347	CDD:275381	9/35 (26%)
		AMN1	347..524	CDD:187754	40/207 (19%)
		leucine-rich repeat	348..373	CDD:275381	4/28 (14%)
		leucine-rich repeat	374..398	CDD:275381	3/37 (8%)
		leucine-rich repeat	399..424	CDD:275381	6/56 (11%)
		leucine-rich repeat	425..450	CDD:275381	8/24 (33%)
		leucine-rich repeat	451..475	CDD:275381	10/37 (27%)
		leucine-rich repeat	476..501	CDD:275381	4/14 (29%)
AgaP_AGAP011911	XP_320618.4	F-box-like	51..94	CDD:289689	16/42 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900