DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and AgaP_AGAP012123

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_320406.4	Gene:	AgaP_AGAP012123 / 1280554	VectorBaseID:	AGAP012123	Length:	462	Species:	Anopheles gambiae

Alignment Length:	539	Identity:	141/539 - (26%)
Similarity:	227/539 - (42%)	Gaps:	136/539 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 NSHCGGSGSNGAATSGGAAIG-GAGAGGAPSWAMDELYQQTELPGLTRTGATTTHHHLLRFTPYA 85
            |:..||:.:.|.    |:.:| |||.||.         .|:.                   ||.:
Mosquito     7 NTTGGGNSAGGK----GSMLGMGAGPGGK---------SQSN-------------------TPQS 39

  Fly    86 LHHRPPHHQLQTLPPALYLQHAAAAAAAAAAAAAHAQHHHHHHHHLPHRPASPESPPPVEGTHIS 150
            |  |...||          ||....                :||||.......:|         .
Mosquito    40 L--RKIGHQ----------QHGGGM----------------NHHHLGGAGKMGQS---------Q 67

  Fly   151 NLFPELL--EQIFEHLPVRDLGR------------AAQVCTAWRDAAY-AKSVWKGV-------E 193
            ...|::|  ||:.:  ..|.|.|            .||||..|||..| :...|.|:       |
Mosquito    68 LALPQILTIEQLLQ--DERFLARFFLYFTSYERCTLAQVCQKWRDLLYRSPRYWSGLVPVLQCRE 130

  Fly   194 AKLHLKRSSPSLFNCLVKRGIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSV 258
            .:....:....|:|.|::|....|.::                      |..:...::|.|:|.:
Mosquito   131 LRQTTNQDRVKLYNSLIRRSFHAVCLM----------------------GATDEDALDLVHSFPL 173

  Fly   259 DLPNLKTLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWG--LKKLKHLNLR 321
            ...::.:|.|. |..|:|..|..:..||::|..|||.||..||..||    |.  ..::..|:|.
Mosquito   174 ASKHVHSLSLR-CSSISDRGLEALLDHLQSLFELELAGCNEITEAGL----WACLTPRIVSLSLA 233

  Fly   322 SCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLT-SLKSINLSFCVSV 385
            .|.:::|:.:|.:|.......|.:||        ...::|.|||:.:...: ||..:.|..|..:
Mosquito   234 DCINVADEAVGAVAQLLPSLYEFSLQ--------AYHVTDAALGYFSPKQSHSLSILRLQSCWEL 290

  Fly   386 TDSGLKHLAR-MPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLY 449
            |:.|:.::.. :|.|..|:|..|..::|.|:..:.|....:.:||:|:|.:|:|.||.:||..|.
Mosquito   291 TNHGVVNIVHSLPHLTVLSLSGCSKVTDDGVELIAENLQKLRALDLSWCPRITDAALEYIACDLN 355

  Fly   450 RLRSLSLNQC-QITDHGMLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQL 513
            :|..|:|::| .|||.|:..|:..| .|..|.:..|::|.|.|||.|. .:.||:.:.|.||..|
Mosquito   356 QLEELTLDRCVHITDIGVGYISTML-SLSALFLRWCTQIRDFGLQHLC-SMRNLQVLSLAGCPLL 418

  Fly   514 SSKGIDIIMKLPKLQKLNL 532
            :|.|:..:::|..||:|.|
Mosquito   419 TSSGLSSLIQLRHLQELEL 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	15/55 (27%)
		AMN1	<226..>334	CDD:187754	28/109 (26%)
		leucine-rich repeat	236..256	CDD:275381	3/19 (16%)
		leucine-rich repeat	263..288	CDD:275381	8/24 (33%)
		leucine-rich repeat	289..314	CDD:275381	11/26 (42%)
		leucine-rich repeat	315..347	CDD:275381	7/31 (23%)
		AMN1	347..524	CDD:187754	57/179 (32%)
		leucine-rich repeat	348..373	CDD:275381	4/25 (16%)
		leucine-rich repeat	374..398	CDD:275381	5/24 (21%)
		leucine-rich repeat	399..424	CDD:275381	7/24 (29%)
		leucine-rich repeat	425..450	CDD:275381	11/24 (46%)
		leucine-rich repeat	451..475	CDD:275381	10/24 (42%)
		leucine-rich repeat	476..501	CDD:275381	9/24 (38%)
AgaP_AGAP012123	XP_320406.4	leucine-rich repeat	178..202	CDD:275381	8/24 (33%)
		AMN1	179..396	CDD:187754	71/230 (31%)
		leucine-rich repeat	227..252	CDD:275381	6/24 (25%)
		leucine-rich repeat	253..278	CDD:275381	7/32 (22%)
		leucine-rich repeat	279..304	CDD:275381	5/24 (21%)
		leucine-rich repeat	305..330	CDD:275381	7/24 (29%)
		leucine-rich repeat	331..356	CDD:275381	11/24 (46%)
		leucine-rich repeat	357..381	CDD:275381	10/24 (42%)
		leucine-rich repeat	382..406	CDD:275381	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820