DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and AgaP_AGAP005622

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_315632.3	Gene:	AgaP_AGAP005622 / 1276307	VectorBaseID:	AGAP005622	Length:	451	Species:	Anopheles gambiae

Alignment Length:	331	Identity:	75/331 - (22%)
Similarity:	117/331 - (35%)	Gaps:	74/331 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 LEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLF--------------- 206
            :..:|:||...|...|:.||..||...:....:|.::..:..:::..:.|
Mosquito    15 ITNVFQHLDHPDRLNASTVCWHWRSVIFQPRFFKRIQFDVAREQNKKNSFFLQKLAHIVSEAKVT 79

  Fly   207 --NCLVKRGIKKVQIL-SLRRSLKDLVLGV-PALTSLNLSGCF-NVADMN---------LGHAFS 257
              :|.:.......:|| .|.:|.:.|.|.: |...:|...|.| :..:.|         |....|
Mosquito    80 FDSCNLYDVELTAEILYKLSKSARLLSLSILPKYATLVTPGRFYSEEEWNYILKLFVQPLIALLS 144

  Fly   258 VDLPNLKTLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRS 322
            ...|.|::|||. |.:|       :|.|..:..||                   ..|.:||. |.
Mosquito   145 RKNPPLRSLDLG-CSEI-------LALHASDFLTL-------------------TAKPQHLE-RL 181

  Fly   323 CWHISDQGIGH--LAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSV 385
            .:....|..||  |........|....|..|.| |...|.||.|    |.|..|....|...|..
Mosquito   182 AFATVKQDPGHYPLGLIEPPLLEKCTALRVLSL-DYDSLCDEVL----QTLQLLPLRQLIVHVHG 241

  Fly   386 TDS---GLKHLA------RMPKLE-QLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQA 440
            .|.   ||...|      :.|:.| .|.|.......:|...::......:..|.|.||:||:.:|
Mosquito   242 IDEDHFGLSEEAWASFRSKNPETELHLTLVCAYEAVEILHTHILRPSMPLTHLKVLFCEKINCEA 306

  Fly   441 LTHIAQ 446
            |.::::
Mosquito   307 LEYLSR 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	9/32 (28%)
		AMN1	<226..>334	CDD:187754	27/120 (23%)
		leucine-rich repeat	236..256	CDD:275381	5/29 (17%)
		leucine-rich repeat	263..288	CDD:275381	8/24 (33%)
		leucine-rich repeat	289..314	CDD:275381	2/24 (8%)
		leucine-rich repeat	315..347	CDD:275381	8/33 (24%)
		AMN1	347..524	CDD:187754	30/110 (27%)
		leucine-rich repeat	348..373	CDD:275381	10/24 (42%)
		leucine-rich repeat	374..398	CDD:275381	7/32 (22%)
		leucine-rich repeat	399..424	CDD:275381	4/25 (16%)
		leucine-rich repeat	425..450	CDD:275381	8/22 (36%)
		leucine-rich repeat	451..475	CDD:275381
		leucine-rich repeat	476..501	CDD:275381
AgaP_AGAP005622	XP_315632.3	F-box	5..50	CDD:279040	10/34 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910