DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and AgaP_AGAP004167

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_313054.2	Gene:	AgaP_AGAP004167 / 1273991	VectorBaseID:	AGAP004167	Length:	384	Species:	Anopheles gambiae

Alignment Length:	385	Identity:	91/385 - (23%)
Similarity:	154/385 - (40%)	Gaps:	64/385 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 HISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNC--LV 210
            |..:|..||:.:||::||:||:..|:.||..|....:::......:.:|:|..|.|.|...  |:
Mosquito    10 HFDDLPFELVCEIFDYLPLRDVKTASSVCQRWNAIIFSEVYIHRFQLQLNLDYSLPVLKQMAQLL 74

  Fly   211 KRGIKKVQILSLRRS---------LKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDL---PNL 263
            :...::...:.||.:         |:.:.|.:..|.|.:.|..||:||..:....|..|   ..|
Mosquito    75 EASDREYYSVVLRANLGSPLTDARLRIVKLMIRLLASRSESLYFNMADFRIESCVSERLLRGRKL 139

  Fly   264 KTLD-----LSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSC 323
            :.:|     :.|...:.::.|..|.::...|..|.:.. .||.|...|:   .|..||||.|..
Mosquito   140 QVIDTRAKYIPLGMGLKESMLAAICEYAVELVDLVIAE-MNINNPKALV---PLSSLKHLKLLL- 199

  Fly   324 WHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDS 388
              |||        :..........:...||:                       |||. :.|||.
Mosquito   200 --ISD--------YYPYVKPPEPPINLPGLE-----------------------NLSL-IKVTDE 230

  Fly   389 GLKHLARMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRS 453
            .. |..|:..|::..:.|....:...|.::|:..:.::.|.:.|..: |.|| ..|...|.|..:
Mosquito   231 SC-HYFRVDNLKRFFIHSTGTDAPRTMDFITQNITQVSRLCLHFTAR-SIQA-EMIFGWLDRFPN 292

  Fly   454 -LSLNQCQITDHG-MLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCT 511
             |:|....:...| :||.....:.|:.|....| .:....|..|.|.|..|:.:.|.||:
Mosquito   293 LLALELAGVALPGDVLKQLSPANRLQKLIFVSC-HLETLQLDGLLEKLAKLRLLCLDGCS 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	13/40 (33%)
		AMN1	<226..>334	CDD:187754	31/115 (27%)
		leucine-rich repeat	236..256	CDD:275381	7/19 (37%)
		leucine-rich repeat	263..288	CDD:275381	5/29 (17%)
		leucine-rich repeat	289..314	CDD:275381	7/24 (29%)
		leucine-rich repeat	315..347	CDD:275381	8/31 (26%)
		AMN1	347..524	CDD:187754	38/167 (23%)
		leucine-rich repeat	348..373	CDD:275381	2/24 (8%)
		leucine-rich repeat	374..398	CDD:275381	8/23 (35%)
		leucine-rich repeat	399..424	CDD:275381	4/24 (17%)
		leucine-rich repeat	425..450	CDD:275381	7/24 (29%)
		leucine-rich repeat	451..475	CDD:275381	5/25 (20%)
		leucine-rich repeat	476..501	CDD:275381	7/24 (29%)
AgaP_AGAP004167	XP_313054.2	F-box-like	11..>48	CDD:289689	13/36 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910