DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and AgaP_AGAP003285

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_307793.5	Gene:	AgaP_AGAP003285 / 1269187	VectorBaseID:	AGAP003285	Length:	841	Species:	Anopheles gambiae

Alignment Length:	727	Identity:	165/727 - (22%)
Similarity:	254/727 - (34%)	Gaps:	245/727 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATNTELLPFHHQTIAVLNNLNSHCGGSGSNGAATSGGAAIGGAGAGG-----APSWA------- 53
            :.|||  ...|||.::.:  |....||||..|    ||.  ||.|.||     .|..|
Mosquito   147 LLTNT--YQQHHQRLSPV--LRGPPGGSGGGG----GGG--GGGGGGGYHHPDEPQSALGGLSEA 201

  Fly    54 --------MDELYQQTELPGLTRTGATTTHHHLLRFTPYALHHRPPHH----QLQTL-------- 98
                    ||.||.|    |..|..|..|...|.|....:.::...::    .:..:
Mosquito   202 DRYFLEEKMDALYIQ----GAIRRNANATPSSLTRNQSSSSNNTERYYLENENIDAIYNFCRRNG 262

  Fly    99 ----------PPALYLQHAAAAAAAAAAAAAHAQHH--HHHHHHLPHRPASPE------------ 139
                      ||.....|.|..||:.|::||.:|..  .....||..|.:|||
Mosquito   263 GGGGGGGIGPPPGTVAAHNAHNAASKASSAAQSQVDCLDSSSPHLLRRASSPETSGSDRYLLDRI 327

  Fly   140 ---------------------------------------------------------SPPP---- 143
                                                                     ||.|
Mosquito   328 RGSPAFQSPRGTHLKAVGSADFIDGRIPLTKSQHYTDGLSRYGRFSPNLDQGYHTLVSPSPSGQQ 392

  Fly   144 ---------VEGTHISN------------------------------------------------ 151
                     ..|||.|.
Mosquito   393 QSTIPASWTTGGTHGSGGGGTNSTSSSHGSPAQTNTPVGGNGSANGNGPCGRSIDGATILTSLGN 457

  Fly   152 -----------LF----PELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRS 201
                       ||    .||:.:|||.|...:|...|:||..:....:..::||.::.|......
Mosquito   458 GHGTSLYRAGPLFDRMPDELMVRIFEWLDSSELCNIARVCRRFESVIWNPALWKIIKIKGEENSG 522

  Fly   202 SPSLFNCLVKRGIKKVQILSLRRSLKDLVLGV-PALTSLNLS-GCFNVADMNLGHAFSVDLPNLK 264
            .         |.||.:    |||.......|. |.:..:.|: || .:.|..| ...|...|.:.
Mosquito   523 D---------RAIKTI----LRRLCGQTRNGACPGVERVLLADGC-RLTDRGL-QLLSRRCPEIT 572

  Fly   265 TLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCNIT----NTGL-----LLIAWGLKKLKHLNL 320
            .|.:.....||:.:|..:.....||:.|::.||..||    |.||     ||       |::|:|
Mosquito   573 HLQIQNSVTITNQALSDLVTKCTNLQHLDITGCAQITCININPGLEPPRRLL-------LQYLDL 630

  Fly   321 RSCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSV 385
            ..|..|.|.||       :..|.....|.||.|:.|.:::|..|..|.....:|:.:::|.|.||
Mosquito   631 TDCASICDAGI-------KVIARNCPLLVYLYLRRCIQVTDAGLKFIPNFCIALRELSVSDCTSV 688

  Fly   386 TDSGLKHLARM-PKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLY 449
            ||.||..||:: ..|..|::..||.:||.|:..:......:..|:...|:.:||.::..:|:...
Mosquito   689 TDFGLYELAKLGATLRYLSVAKCDQVSDAGLKVIARRCYKLRYLNARGCEAVSDDSINVLARSCP 753

  Fly   450 RLRSLSLNQCQITDHGMLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLS 514
            |||:|.:.:|.::|.|:..:|::...|:.|::..|..|||:|:|.:|.....|:.:::..| |:|
Mosquito   754 RLRALDIGKCDVSDAGLRALAESCPNLKKLSLRNCDMITDRGIQCIAYYCRGLQQLNIQDC-QIS 817

  Fly   515 SKGIDIIMKLPK 526
            .:|...:.|..|
Mosquito   818 IEGYRAVKKYCK 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	13/103 (13%)
		AMN1	<226..>334	CDD:187754	33/118 (28%)
		leucine-rich repeat	236..256	CDD:275381	5/20 (25%)
		leucine-rich repeat	263..288	CDD:275381	4/24 (17%)
		leucine-rich repeat	289..314	CDD:275381	11/33 (33%)
		leucine-rich repeat	315..347	CDD:275381	9/31 (29%)
		AMN1	347..524	CDD:187754	53/177 (30%)
		leucine-rich repeat	348..373	CDD:275381	8/24 (33%)
		leucine-rich repeat	374..398	CDD:275381	11/24 (46%)
		leucine-rich repeat	399..424	CDD:275381	7/24 (29%)
		leucine-rich repeat	425..450	CDD:275381	5/24 (21%)
		leucine-rich repeat	451..475	CDD:275381	7/23 (30%)
		leucine-rich repeat	476..501	CDD:275381	9/24 (38%)
AgaP_AGAP003285	XP_307793.5	F-box-like	470..511	CDD:289689	11/40 (28%)
		leucine-rich repeat	483..509	CDD:275381	6/25 (24%)
		leucine-rich repeat	510..544	CDD:275381	10/46 (22%)
		AMN1	<542..691	CDD:187754	47/164 (29%)
		leucine-rich repeat	545..570	CDD:275381	6/26 (23%)
		leucine-rich repeat	571..592	CDD:275381	4/20 (20%)
		leucine-rich repeat	597..624	CDD:275381	9/26 (35%)
		leucine-rich repeat	625..650	CDD:275381	9/31 (29%)
		AMN1	643..814	CDD:187754	50/170 (29%)
		leucine-rich repeat	651..676	CDD:275381	8/24 (33%)
		leucine-rich repeat	677..702	CDD:275381	11/24 (46%)
		leucine-rich repeat	703..728	CDD:275381	7/24 (29%)
		leucine-rich repeat	729..754	CDD:275381	5/24 (21%)
		leucine-rich repeat	755..779	CDD:275381	7/23 (30%)
		leucine-rich repeat	780..804	CDD:275381	9/23 (39%)
		leucine-rich repeat	806..830	CDD:275381	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810