DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and si:dkey-59l11.10

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_017211008.1	Gene:	si:dkey-59l11.10 / 108183670	ZFINID:	ZDB-GENE-120703-17	Length:	1028	Species:	Danio rerio

Alignment Length:	371	Identity:	85/371 - (22%)
Similarity:	152/371 - (40%)	Gaps:	91/371 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 ILSLRRSLKDLVL---GVPALTSLNLSGC-FNVADMNLGHAF----SVDLPNLKTLDLSLCKQIT 275
            |..:.:.:||.:.   |:.|..|:||..| ..|.|..|....    ..|..:.:.|..:.|..|:
Zfish   505 IRRITQYIKDQIKRDNGLSAERSINLFLCLLEVKDQTLAREIQEFVKSDKHSEEYLSPAHCSTIS 569

  Fly   276 -------------DTSLGRIAQHLRNLETLELGGC-------CNITNTGLLLIAWGLKK----LK 316
                         |::....:...|...|..:..|       ||:|......::..|:.    |:
Zfish   570 YMIEMSEEPLDELDSNKFNTSAEGRRRLTAAVRNCRRALLQWCNLTVECCESLSSALQSSNCVLR 634

  Fly   317 HLNLRSCWHISDQGIGHLA-GFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTS----LKS 376
            .|:| |..|:.|.|:..|: |...:    :.:|:.|.|..| :|:.:....::..|.|    |:.
Zfish   635 ELDL-SNNHLQDSGVKKLSDGLKSQ----HCKLDTLRLAAC-KLTVQCCESLSSALQSSNCVLRE 693

  Fly   377 INLSFCVSVTDSGLKHL-----ARMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKI 436
            ::|| ...:.|||:|.|     ::..||:.|.|.:|                   :|.|..|:.:
Zfish   694 LDLS-NNDLQDSGVKKLSDGLKSQHCKLDTLRLAAC-------------------NLTVECCESL 738

  Fly   437 SD--QALTHIAQGLYRLRSLSLNQCQITDHGMLKIA---KALH-ELENLNIGQCSRITDKGLQTL 495
            |.  |:...:      ||.|.|:...:.|.|:.|::   |:.| :|:.|.:..| .:|::|...|
Zfish   739 SSALQSSNCV------LRELDLSNNHLQDSGVKKLSDGLKSQHCKLDTLRLSGC-MVTEEGCGFL 796

  Fly   496 AEDLT----NLKTIDLYGCTQLSSKGIDII---MKLPK--LQKLNL 532
            :..||    :|:.:|| ........|:.::   ::.|.  |.||||
Zfish   797 SSALTSNPSHLRELDL-SYNHPGDSGVKLLSEQLEDPNYTLDKLNL 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689
		AMN1	<226..>334	CDD:187754	30/139 (22%)
		leucine-rich repeat	236..256	CDD:275381	7/20 (35%)
		leucine-rich repeat	263..288	CDD:275381	4/37 (11%)
		leucine-rich repeat	289..314	CDD:275381	6/31 (19%)
		leucine-rich repeat	315..347	CDD:275381	9/32 (28%)
		AMN1	347..524	CDD:187754	46/198 (23%)
		leucine-rich repeat	348..373	CDD:275381	6/24 (25%)
		leucine-rich repeat	374..398	CDD:275381	8/28 (29%)
		leucine-rich repeat	399..424	CDD:275381	4/24 (17%)
		leucine-rich repeat	425..450	CDD:275381	5/26 (19%)
		leucine-rich repeat	451..475	CDD:275381	9/27 (33%)
		leucine-rich repeat	476..501	CDD:275381	8/28 (29%)
si:dkey-59l11.10	XP_017211008.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010