DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and LOC100536129

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_021335138.1	Gene:	LOC100536129 / 100536129	-ID:	-	Length:	1263	Species:	Danio rerio

Alignment Length:	394	Identity:	102/394 - (25%)
Similarity:	151/394 - (38%)	Gaps:	110/394 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 PSWAMD-ELYQQTELPGLTRTGATTTHHHLLRFTPYALHHRPPHHQLQTLPPALYLQHAAAAAAA 113
            |.|.:: .|.:||.: .|.|   |||...:.|.||.    |.|       |..:.::
Zfish   925 PKWELNGSLREQTPV-SLIR---TTTPAPVFRPTPC----RSP-------PKCVQME-------- 966

  Fly   114 AAAAAAHAQHHHHHHHHLPHRPASPESPPP-----VEG-THISNLFPELLEQIFEHLPVRDLGRA 172
                           .|:...|  |.||||     .:| .|:  |..|:...:|.||..:||...
Zfish   967 ---------------RHVIRPP--PISPPPDRLPLDDGKNHV--LRREVWMGVFSHLIHKDLCVC 1012

  Fly   173 AQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGIKKVQILSL--------RRSLKDL 229
            ..||..|......|.:|..::.. ..|..:|.:.:.:::|     |.:||        ::.|..|
Zfish  1013 MSVCKTWNRWCCDKRLWTKIDLN-RCKSITPLMLSGIIRR-----QPVSLDLSWTNISKKQLSWL 1071

  Fly   230 VLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDL------------SLCKQITDTSLGRI 282
            :..:|.|..|.|:||...|   :....:...|.|:.||:            .|....||...|::
Zfish  1072 INRLPGLRVLLLAGCSWAA---VSALCTSSCPLLRNLDVQWVEGLKDNQIRDLLSPPTDNRPGQL 1133

  Fly   283 --AQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGN 345
              ...|||:|.|.|.| .:||:|.|.||...:..|..|:|..|.||:||.:..|      ||.|.
Zfish  1134 DCRSKLRNVEDLCLAG-LDITDTSLKLIIKHMPLLSQLDLSYCNHITDQSVNIL------TAAGT 1191

  Fly   346 LQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLNLRSCDNI 410
            ...:                       ||..||||.|..|||..|.:..|...:.|::||.|..:
Zfish  1192 TTRD-----------------------SLTHINLSVCNRVTDLSLTYFKRCGNICQIDLRYCKQV 1233

  Fly   411 SDIG 414
            :..|
Zfish  1234 TKEG 1237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	11/40 (28%)
		AMN1	<226..>334	CDD:187754	38/121 (31%)
		leucine-rich repeat	236..256	CDD:275381	6/19 (32%)
		leucine-rich repeat	263..288	CDD:275381	8/38 (21%)
		leucine-rich repeat	289..314	CDD:275381	10/24 (42%)
		leucine-rich repeat	315..347	CDD:275381	12/31 (39%)
		AMN1	347..524	CDD:187754	17/68 (25%)
		leucine-rich repeat	348..373	CDD:275381	0/24 (0%)
		leucine-rich repeat	374..398	CDD:275381	11/23 (48%)
		leucine-rich repeat	399..424	CDD:275381	5/16 (31%)
		leucine-rich repeat	425..450	CDD:275381
		leucine-rich repeat	451..475	CDD:275381
		leucine-rich repeat	476..501	CDD:275381
LOC100536129	XP_021335138.1	cupin_like	198..298	CDD:328732
		zf-CXXC	<550..586	CDD:251032
		PHD_KDM2B	596..657	CDD:277114
		F-box-like	995..1033	CDD:315592	11/37 (30%)
		leucine-rich repeat	1004..1026	CDD:275381	6/21 (29%)
		AMN1	1024..1239	CDD:332986	67/253 (26%)
		leucine-rich repeat	1029..1053	CDD:275381	4/29 (14%)
		leucine-rich repeat	1054..1077	CDD:275381	4/22 (18%)
		leucine-rich repeat	1078..1101	CDD:275381	6/25 (24%)
		leucine-rich repeat	1102..1141	CDD:275381	8/38 (21%)
		leucine-rich repeat	1142..1166	CDD:275381	10/24 (42%)
		leucine-rich repeat	1167..1196	CDD:275381	12/57 (21%)
		leucine-rich repeat	1197..1221	CDD:275381	11/23 (48%)
		leucine-rich repeat	1222..1246	CDD:275381	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900