DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and fbxl13

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_002933148.2	Gene:	fbxl13 / 100496930	XenbaseID:	XB-GENE-6042355	Length:	808	Species:	Xenopus tropicalis

Alignment Length:	510	Identity:	129/510 - (25%)
Similarity:	226/510 - (44%)	Gaps:	111/510 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 SPPPVEG-THISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVE---------- 193
            |.|..|| .::|.|.|:.:.:||..:.:.||.|:||||.:|:..:...|:|..::
Frog   217 SSPLREGEDNVSQLPPKAVLKIFSFVDLIDLARSAQVCRSWKIISQNSSLWSSIDFSSVRQYVQD 281

  Fly   194 ---------AKLHL----KRSSPSL----FNCLVKRGIKKVQILSLR-------RSLKDLVLGVP 234
                     .:|::    .||..||    |..:.:  .|.:|.|:|.       .|::.:..|.|
Frog   282 KFVVNTLRKCRLYVIRLNFRSCSSLHWPTFKAIGE--CKNLQDLNLSECIHLNDESIRIICEGCP 344

  Fly   235 ALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTSLGRIAQHLRN------LETLE 293
            ||..||:|.. :|.:..| ...|..|.||:.|.|:.|::.||..|    |:|.:      |..|:
Frog   345 ALLYLNISHT-DVTNATL-RIVSRCLLNLQFLSLAYCRKFTDKGL----QYLGSGKGCPKLIYLD 403

  Fly   294 LGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQ------------------GIGHLAGFSRE 340
            |.||..|:..|...:|.|...|:.|.:...:.::|:                  |..||:..:.:
Frog   404 LSGCTQISVDGFTFLAAGCNSLQQLKINDMFTLTDKCITALLEKCQNILSISLLGSPHLSDVAFK 468

  Fly   341 TAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLNLR 405
            ......:|..:.::...|::|.::..|.:...:|..|.::.|..:||..||.::.:..:..||:.
Frog   469 VLAQGRKLAKIRIEGNNRITDSSIKAICKFCANLNHIYVADCQKITDVSLKAISVLKNITILNVA 533

  Fly   406 SCDNISDIGMAYLTEGGSG--INSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQ-------- 460
            .|..|||.|:..:.||.||  |..|:::.|.::||.:|..|||..:.|..|||..|:
Frog   534 DCIRISDPGVRQVLEGPSGTKIRELNLTNCIRVSDLSLLRIAQKCHNLTYLSLRYCENLTDSGFE 598

  Fly   461 -----------------ITDHGMLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLY 508
                             |||.|:..:. |...::.|::.:|..|:|.|:|...:...:|:.:||.
Frog   599 LLGNMASLISIDLSGTNITDQGLSALG-AHSTIKELSVSECFGISDIGIQKFCQQSRDLEQLDLS 662

  Fly   509 GCTQLSS---KGIDIIMKL---------PKLQKLNLGLWLVRXCVH-H--DCNAC 548
            .|:|:::   |.:....||         ||:..|:: .:|...|.: |  |.:.|
Frog   663 HCSQVTNNTVKTVAFCCKLLTSVNIAGCPKVTDLSI-QYLSGVCSYLHVLDISGC 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	14/40 (35%)
		AMN1	<226..>334	CDD:187754	34/131 (26%)
		leucine-rich repeat	236..256	CDD:275381	6/19 (32%)
		leucine-rich repeat	263..288	CDD:275381	9/24 (38%)
		leucine-rich repeat	289..314	CDD:275381	9/24 (38%)
		leucine-rich repeat	315..347	CDD:275381	6/49 (12%)
		AMN1	347..524	CDD:187754	53/206 (26%)
		leucine-rich repeat	348..373	CDD:275381	4/24 (17%)
		leucine-rich repeat	374..398	CDD:275381	7/23 (30%)
		leucine-rich repeat	399..424	CDD:275381	9/24 (38%)
		leucine-rich repeat	425..450	CDD:275381	9/24 (38%)
		leucine-rich repeat	451..475	CDD:275381	10/48 (21%)
		leucine-rich repeat	476..501	CDD:275381	6/24 (25%)
fbxl13	XP_002933148.2	Sfi1	<103..>206	CDD:369887
		F-box-like	227..271	CDD:372399	15/43 (35%)
		leucine-rich repeat	242..266	CDD:275381	8/23 (35%)
		leucine-rich repeat	267..287	CDD:275381	1/19 (5%)
		leucine-rich repeat	295..308	CDD:275381	4/12 (33%)
		AMN1	318..580	CDD:187754	72/267 (27%)
		leucine-rich repeat	320..345	CDD:275381	5/24 (21%)
		leucine-rich repeat	346..370	CDD:275381	8/25 (32%)
		leucine-rich repeat	371..391	CDD:275381	8/23 (35%)
		leucine-rich repeat	399..424	CDD:275381	9/24 (38%)
		leucine-rich repeat	425..450	CDD:275381	3/24 (13%)
		leucine-rich repeat	451..475	CDD:275381	3/23 (13%)
		leucine-rich repeat	476..501	CDD:275381	4/24 (17%)
		leucine-rich repeat	502..520	CDD:275381	6/17 (35%)
		leucine-rich repeat	527..554	CDD:275381	11/26 (42%)
		AMN1	538..697	CDD:187754	43/159 (27%)
		leucine-rich repeat	555..580	CDD:275381	9/24 (38%)
		leucine-rich repeat	581..605	CDD:275381	5/23 (22%)
		leucine-rich repeat	606..626	CDD:275381	4/20 (20%)
		leucine-rich repeat	630..655	CDD:275381	6/24 (25%)
		AMN1	656..>753	CDD:187754	16/62 (26%)
		leucine-rich repeat	656..681	CDD:275381	6/24 (25%)
		leucine-rich repeat	682..707	CDD:275381	5/25 (20%)
		leucine-rich repeat	708..733	CDD:275381	3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010