DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and fbxl14

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_031754473.1	Gene:	fbxl14 / 100487109	XenbaseID:	XB-GENE-968324	Length:	400	Species:	Xenopus tropicalis

Alignment Length:	389	Identity:	246/389 - (63%)
Similarity:	305/389 - (78%)	Gaps:	0/389 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 THISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVK 211
            ||||.||||||..||.:|.|||.|||||||.|||||||.||||:|.||||||:|::||||..|..
Frog     3 THISCLFPELLAMIFSYLDVRDKGRAAQVCAAWRDAAYHKSVWRGTEAKLHLRRANPSLFPSLQA 67

  Fly   212 RGIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITD 276
            |||:|||||||||||..::.|:|.:.|||||||:|:.|..|||||..::.:|::|:||||||:||
Frog    68 RGIRKVQILSLRRSLSYVIQGLPDIESLNLSGCYNLTDNGLGHAFVQEIGSLRSLNLSLCKQVTD 132

  Fly   277 TSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRET 341
            :|||||||:|:.|:.||||||.||||||||||||||..||.||||||.|:||.|||||||.:|..
Frog   133 SSLGRIAQYLKGLQVLELGGCTNITNTGLLLIAWGLHGLKSLNLRSCRHVSDVGIGHLAGMTRSA 197

  Fly   342 AEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLNLRS 406
            |||.|.||.|.|||||:|:|.||.||::||..|:.:|||||..::|:||.||:.|..|..|||||
Frog   198 AEGCLGLEQLTLQDCQKLTDLALKHISRGLQGLRVLNLSFCGGISDAGLLHLSHMGGLRSLNLRS 262

  Fly   407 CDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQITDHGMLKIAK 471
            ||||||.|:.:|..|...::.||||||||:.||:|.:||||||.|:||||..|.|:|.|:.::.:
Frog   263 CDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLYGLKSLSLCSCHISDDGINRMVR 327

  Fly   472 ALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGIDIIMKLPKLQKLNLGLW 535
            .:|.|..||||||.|||||||:.:||.|:.|..|||||||:::.||::.|.:||.|:.||||||
Frog   328 QMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKKGLERITQLPCLKVLNLGLW 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	31/40 (78%)
		AMN1	<226..>334	CDD:187754	70/107 (65%)
		leucine-rich repeat	236..256	CDD:275381	12/19 (63%)
		leucine-rich repeat	263..288	CDD:275381	18/24 (75%)
		leucine-rich repeat	289..314	CDD:275381	21/24 (88%)
		leucine-rich repeat	315..347	CDD:275381	22/31 (71%)
		AMN1	347..524	CDD:187754	98/176 (56%)
		leucine-rich repeat	348..373	CDD:275381	16/24 (67%)
		leucine-rich repeat	374..398	CDD:275381	12/23 (52%)
		leucine-rich repeat	399..424	CDD:275381	15/24 (63%)
		leucine-rich repeat	425..450	CDD:275381	16/24 (67%)
		leucine-rich repeat	451..475	CDD:275381	9/23 (39%)
		leucine-rich repeat	476..501	CDD:275381	17/24 (71%)
fbxl14	XP_031754473.1	F-box-like	5..46	CDD:403981	31/40 (78%)
		AMN1	90..243	CDD:187754	99/152 (65%)
		leucine-rich repeat	92..118	CDD:275381	14/25 (56%)
		leucine-rich repeat	119..144	CDD:275381	18/24 (75%)
		leucine-rich repeat	145..170	CDD:275381	21/24 (88%)
		leucine-rich repeat	171..203	CDD:275381	22/31 (71%)
		leucine-rich repeat	204..229	CDD:275381	16/24 (67%)
		AMN1	228..388	CDD:187754	86/159 (54%)
		leucine-rich repeat	230..254	CDD:275381	12/23 (52%)
		leucine-rich repeat	255..280	CDD:275381	15/24 (63%)
		leucine-rich repeat	281..304	CDD:275381	14/22 (64%)
		leucine-rich repeat	307..331	CDD:275381	9/23 (39%)
		leucine-rich repeat	332..357	CDD:275381	17/24 (71%)
		leucine-rich repeat	358..382	CDD:275381	12/23 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7765
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H15271
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1348
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	1	1.000	-	-		FOG0008216
OrthoInspector	1	1.000	-	-		oto103437
Panther	1	1.100	-	-	LDO	PTHR13318
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160