DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppa and si:ch73-173p19.1

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_002660968.3	Gene:	si:ch73-173p19.1 / 100332407	ZFINID:	ZDB-GENE-130530-952	Length:	918	Species:	Danio rerio

Alignment Length:	604	Identity:	133/604 - (22%)
Similarity:	227/604 - (37%)	Gaps:	186/604 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GGAAIGGAG---AGGAPSW----------AMDELYQQTE---------------LPGL------- 66
            |.|.|.|.|   :|.:..|          |.||.:.:.|               ||.|
Zfish   321 GYAGIPGVGPPLSGPSHFWGRGQKLVQGDAEDEEHLENEEQQEEEVVPPFNFEGLPRLPFFMENR 385

  Fly    67 TRTGATTTHH-----HLLRFTPYALHHRPPHHQLQTLPPALYLQHAAAAAAAAAAAAAHAQH--H 124
            .|.|....||     :.||             :::...||...:..|...||..||....|.  |
Zfish   386 ARGGLDLRHHWPEQGNRLR-------------EVEPDDPADPDEGRALRGAAGQAAVERLQRGAH 437

  Fly   125 HHHHHHLPHRPASPESP-----------------------PPVE-GTHISNLFPELLEQIFEHLP 165
            |...|....:|:.|:.|                       |.:: .:.::.|.|||.|.:..|:
Zfish   438 HDEQHSTHGQPSPPKKPFKTPRVPSLCSMATRATVSLMTAPSMQYSSSLACLTPELAELLLSHM- 501

  Fly   166 VRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGIKKVQILSLRRSLKDL- 229
                                      ...:|...|:....|.|.:::.:......:....|:.|
Zfish   502 --------------------------ARERLLRPRTLELFFGCPLQKFVLNCYPYTTNELLRQLR 540

  Fly   230 ---------VLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTSLGRIAQH 285
                     .|..|.:|...||...|             |..|:.|:||.|.::||:.|    ||
Zfish   541 AFTCLKHLSFLNSPLITDAGLSVLSN-------------LSKLQHLNLSSCSKLTDSCL----QH 588

  Fly   286 ---LRNLETLELGGCCNITNTGLLL-IAWGLKKLKHLNLR----------------------SCW 324
               ||:|..|.|.. ..:::.|||| :..|...|..|:|.                      |..
Zfish   589 ITGLRSLTFLALDQ-TKVSDAGLLLYLQSGSSALCQLSLNQTAITESTLRVLPASVPQLRMLSIK 652

  Fly   325 HISDQGIGHLAGFSRETAEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSG 389
            |.....:..||...      |||..:|   |...:.:.:|..:|.. .||.:::|: .:.|.|..
Zfish   653 HTKVSDVSALAELK------NLQTLHL---DGTGVQENSLQCLASH-PSLSALSLA-GIPVADGN 706

  Fly   390 --LKHLARMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLR 452
              |:.:|.: :|.||.|....:::|.|:::|:. .:.:..||::...:::|..:|.:: .:.||:
Zfish   707 HTLEIIAGL-RLTQLTLPGRHSVTDSGLSFLSR-QTLLLELDLTDYTQLTDHGITQLS-SMTRLK 768

  Fly   453 SLSLNQCQITDHGMLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSS-- 515
            .|||:..|::|.|:..:.: |.||:.|.:.: :.:|.:|:..|...|.:|:.:.| ..||:..
Zfish   769 KLSLSNTQVSDSGLQGLIR-LKELQELCLDR-TAVTSRGVAALITHLPHLQVMGL-ASTQVGDTV 830

  Fly   516 --KGIDIIMKLPKLQKLNL 532
              :|   ::..|:|.||||
Zfish   831 IRRG---LVHCPQLLKLNL 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	6/40 (15%)
		AMN1	<226..>334	CDD:187754	34/143 (24%)
		leucine-rich repeat	236..256	CDD:275381	4/19 (21%)
		leucine-rich repeat	263..288	CDD:275381	11/27 (41%)
		leucine-rich repeat	289..314	CDD:275381	8/25 (32%)
		leucine-rich repeat	315..347	CDD:275381	8/53 (15%)
		AMN1	347..524	CDD:187754	44/182 (24%)
		leucine-rich repeat	348..373	CDD:275381	4/24 (17%)
		leucine-rich repeat	374..398	CDD:275381	6/25 (24%)
		leucine-rich repeat	399..424	CDD:275381	7/24 (29%)
		leucine-rich repeat	425..450	CDD:275381	4/24 (17%)
		leucine-rich repeat	451..475	CDD:275381	8/23 (35%)
		leucine-rich repeat	476..501	CDD:275381	6/24 (25%)
si:ch73-173p19.1	XP_002660968.3	UBA_like_SF	6..43	CDD:304366
		Nop25	116..>169	CDD:286843
		UBQ	187..260	CDD:294102
		AMN1	523..701	CDD:187754	46/206 (22%)
		LRR	<524..710	CDD:227223	48/214 (22%)
		leucine-rich repeat	545..569	CDD:275381	7/36 (19%)
		leucine-rich repeat	570..594	CDD:275381	11/27 (41%)
		leucine-rich repeat	595..620	CDD:275381	8/25 (32%)
		leucine-rich repeat	621..645	CDD:275381	3/23 (13%)
		leucine-rich repeat	646..691	CDD:275381	11/54 (20%)
		leucine-rich repeat	692..766	CDD:275381	17/77 (22%)
		leucine-rich repeat	717..742	CDD:275381	7/25 (28%)
		AMN1	750..>888	CDD:187754	29/104 (28%)
		leucine-rich repeat	767..790	CDD:275381	8/23 (35%)
		leucine-rich repeat	791..815	CDD:275381	6/24 (25%)
		leucine-rich repeat	816..840	CDD:275381	5/27 (19%)
		leucine-rich repeat	841..863	CDD:275381	5/6 (83%)
		leucine-rich repeat	864..888	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101394
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.710