DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppa and Fbxl13

DIOPT Version :9

Sequence 1:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_038962809.1	Gene:	Fbxl13 / 100125363	RGDID:	1642425	Length:	823	Species:	Rattus norvegicus

Alignment Length:	569	Identity:	135/569 - (23%)
Similarity:	236/569 - (41%)	Gaps:	152/569 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 SPESPPPVEGT-------------HISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSV 188
            |.|.|..:||:             .||.|..:.:.|||.:|..:||...:||..:|.......|:
  Rat   217 SLEKPINIEGSFSDFGVTDKRIVFDISVLPDQAVVQIFVYLTFKDLVSCSQVNRSWMSMIQRGSL 281

  Fly   189 WKGVEAKLHLKRSSPSLFNCLVKRGIKKVQILSLRRSLKDLVLGVPALTS---------LNLSGC 244
            |..::... :|..:.   .|:|.. ::|.::..||.:.:..||....|.|         ||:|.|
  Rat   282 WNSIDFST-VKNIAD---RCVVTT-LQKWRLNVLRLNFRGCVLRAKTLKSVSHCKNLQELNVSDC 341

  Fly   245 FNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGL--LL 307
            .:..|.::.| .|...|.:..|:|| ...||:.::..:.::..||:.|.|..|...|:.||  |.
  Rat   342 PSFTDESMRH-ISEGCPGVLYLNLS-NTTITNRTMRLLPRYFHNLQNLSLAYCRKFTDKGLQYLN 404

  Fly   308 IAWGLKKLKHLNLRSCWHISDQGIGHLA------------------------------------- 335
            :..|..||.:|:|..|..||.||..::|
  Rat   405 LGNGCHKLIYLDLSGCTQISVQGFRNIANSCTGIMHLTINDMPTLTDNCVKVLVEKCPRISSVVF 469

  Fly   336 ---------GFSRETA--------EGNLQL----------EYLGLQ-----DCQRLSDEALGHIA 368
                     .|...:|        |||.::          .|.|:.     ||:.|:|.:|..::
  Rat   470 IGSPHISDCAFKALSACDLKKIRFEGNKRITDACFKSVDRNYPGISHIYMVDCKGLTDSSLKSLS 534

  Fly   369 QGLTSLKSINLSFCVSVTDSGLKHLARMP---KLEQLNLRSCDNISDIGMAYLTEGGSGINSLDV 430
            . |..|..:||:.||.:.|.||:.....|   ||.:|||.:|..:.|..:..|:|....::.|::
  Rat   535 V-LKQLTVLNLTNCVRIGDIGLRQFFDGPASVKLRELNLANCSLLGDTSVIRLSERCPNLHYLNL 598

  Fly   431 SFCDKISDQALTHIA-----------------QGL------YRLRSLSLNQC-QITDHGMLKIAK 471
            ..|:.::|.|:.:||                 :||      .:||.:||::| .|||.|:....|
  Rat   599 RNCEHLTDLAIEYIASMLSLISIDLSGTLISNEGLAILSRHRKLREVSLSECVNITDFGIRAFCK 663

  Fly   472 ALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGIDII--------------- 521
            ....||:|::..|:::||..::|:|...|.:.::.:.||.:::..|::|:
  Rat   664 TSLALEHLDVSYCAQLTDDIIKTIAIFCTRITSLHIAGCPKITDGGMEILSARCHYLHILDISGC 728

  Fly   522 MKLPK--LQKLNLGLWLVRXCVHHDCNACAAKEAARGS-------YNSQ 561
            ::|..  ||.|.:|...:|......|.:.::..|.:.|       |:|:
  Rat   729 VQLTDQILQDLQIGCKQLRILKMQFCKSISSAAAQKMSSVVQQQEYSSE 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	13/40 (33%)
		AMN1	<226..>334	CDD:187754	36/118 (31%)
		leucine-rich repeat	236..256	CDD:275381	8/28 (29%)
		leucine-rich repeat	263..288	CDD:275381	5/24 (21%)
		leucine-rich repeat	289..314	CDD:275381	9/26 (35%)
		leucine-rich repeat	315..347	CDD:275381	14/85 (16%)
		AMN1	347..524	CDD:187754	57/233 (24%)
		leucine-rich repeat	348..373	CDD:275381	8/39 (21%)
		leucine-rich repeat	374..398	CDD:275381	9/26 (35%)
		leucine-rich repeat	399..424	CDD:275381	8/24 (33%)
		leucine-rich repeat	425..450	CDD:275381	8/47 (17%)
		leucine-rich repeat	451..475	CDD:275381	10/24 (42%)
		leucine-rich repeat	476..501	CDD:275381	8/24 (33%)
Fbxl13	XP_038962809.1	Sfi1	<134..>214	CDD:400658
		F-box-like	242..286	CDD:403981	14/43 (33%)
		leucine-rich repeat	257..270	CDD:275381	5/12 (42%)
		leucine-rich repeat	282..308	CDD:275381	5/30 (17%)
		AMN1	308..477	CDD:187754	39/170 (23%)
		leucine-rich repeat	309..332	CDD:275381	6/22 (27%)
		leucine-rich repeat	333..358	CDD:275381	7/25 (28%)
		leucine-rich repeat	359..383	CDD:275381	5/24 (21%)
		leucine-rich repeat	384..402	CDD:275381	7/17 (41%)
		leucine-rich repeat	412..437	CDD:275381	9/24 (38%)
		leucine-rich repeat	438..463	CDD:275381	0/24 (0%)
		leucine-rich repeat	464..486	CDD:275381	1/21 (5%)
		leucine-rich repeat	488..513	CDD:275381	4/24 (17%)
		leucine-rich repeat	514..534	CDD:275381	5/19 (26%)
		AMN1	525..733	CDD:187754	54/208 (26%)
		leucine-rich repeat	539..563	CDD:275381	8/23 (35%)
		leucine-rich repeat	567..592	CDD:275381	8/24 (33%)
		leucine-rich repeat	593..617	CDD:275381	6/23 (26%)
		leucine-rich repeat	618..641	CDD:275381	2/22 (9%)
		leucine-rich repeat	642..667	CDD:275381	10/24 (42%)
		leucine-rich repeat	668..693	CDD:275381	8/24 (33%)
		leucine-rich repeat	694..719	CDD:275381	4/24 (17%)
		leucine-rich repeat	720..745	CDD:275381	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820