DRSC/TRiP Functional Genomics Resources

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Protein Alignment RYBP and RYBP

DIOPT Version :9

Sequence 1:NP_001286742.1 Gene:RYBP / 37601 FlyBaseID:FBgn0034763 Length:150 Species:Drosophila melanogaster
Sequence 2:NP_036366.3 Gene:RYBP / 23429 HGNCID:10480 Length:228 Species:Homo sapiens


Alignment Length:209 Identity:86/209 - (41%)
Similarity:103/209 - (49%) Gaps:60/209 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDKKSSPVRRQKRQAK-VIEENFWDCSVCTYRNSAEAFKCRMCDVRKGTSTRKPRLNSALVAQQA 64
            |..|.||. |.||||| ..:|.||||||||:|||||||||.:|||||||||||||:||.|||||.
Human     3 MGDKKSPT-RPKRQAKPAADEGFWDCSVCTFRNSAEAFKCSICDVRKGTSTRKPRINSQLVAQQV 66

  Fly    65 A-------------------------------------------TLPGASV--NMPNGKSASGSR 84
            |                                           |.|.:.:  :.|:..::..|.
Human    67 AQQYATPPPPKKEKKEKVEKQDKEKPEKDKEISPSVTKKNTNKKTKPKSDILKDPPSEANSIQSA 131

  Fly    85 HGSGHDRQRHKRYPARLKNVDRSTAQTREVTVNSVTVFITEYKAKPVSSRRES--------SEQ- 140
            :.:....:.:.....|||||||||||...|||.:|||.||::|.|..||...|        ||| 
Human   132 NATTKTSETNHTSRPRLKNVDRSTAQQLAVTVGNVTVIITDFKEKTRSSSTSSSTVTSSAGSEQQ 196

  Fly   141 ----SFSESNDSRS 150
                |.|||.|..|
Human   197 NQSSSGSESTDKGS 210

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RYBPNP_001286742.1 zf-RanBP 20..43 CDD:279035 18/22 (82%)
RanBP2-type Zn finger 23..42 CDD:275377 16/18 (89%)
RYBPNP_036366.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 10/18 (56%)
zf-RanBP 22..45 CDD:395516 18/22 (82%)
RanBP2-type Zn finger 25..44 CDD:275376 16/18 (89%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 65..156 39/146 (27%)
Interaction with GABPB1 and FANK1. /evidence=ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:27060496 143..226 6/10 (60%)
YAF2_RYBP 145..176 CDD:407339 5/8 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 172..228


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141018
Domainoid 1 1.000 51 1.000 Domainoid score I11598
eggNOG 1 0.900 - - E1_KOG4477
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 125 1.000 Inparanoid score I4714
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1634090at2759
OrthoFinder 1 1.000 - - FOG0003518
OrthoInspector 1 1.000 - - otm41962
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR12920
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5806
SonicParanoid 1 1.000 - - X3403
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.890

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