DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYBP and YAF2

DIOPT Version :9

Sequence 1:	NP_001286742.1	Gene:	RYBP / 37601	FlyBaseID:	FBgn0034763	Length:	150	Species:	Drosophila melanogaster
Sequence 2:	XP_011536030.1	Gene:	YAF2 / 10138	HGNCID:	17363	Length:	238	Species:	Homo sapiens

Alignment Length:	216	Identity:	74/216 - (34%)
Similarity:	91/216 - (42%)	Gaps:	66/216 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDKKSSPVRRQKRQAKVIEENFWDCSVCTYRNSAEAFKCRMCDVRKGTST--------------- 50
            |..|.||.|.:::.....:|.:|||||||:|||||||||.||||||||||
Human     1 MGDKKSPTRPKRQPKPSSDEGYWDCSVCTFRNSAEAFKCMMCDVRKGTSTRMKNHEIISFLKEGE 65

  Fly    51 -------------------------------------------RKPRLNSALVAQQAA---TLPG 69
                                                       ||||..|.|||||..   ..|.
Human    66 KKKLDHLPVTGVLLLGNLHRSTLFEVIVSASRTKEPLKFPISGRKPRPVSQLVAQQVTQQFVPPT 130

  Fly    70 ASVNMPNGK-SASGSRHGSGHDRQRHKRYPARLKNVDRSTAQTREVTVNSVTVFITEYKAK---- 129
            .|......| ....|...:...:..||:...||||||||:||..||||..:||.||::|.|
Human   131 QSKKEKKDKVEKEKSEKETTSKKNSHKKTRPRLKNVDRSSAQHLEVTVGDLTVIITDFKEKTKSP 195

  Fly   130 PVSSRRESSEQSFSESNDSRS 150
            |.||...:.:.|.|.|:...:
Human   196 PASSAASADQHSQSGSSSDNT 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYBP	NP_001286742.1	zf-RanBP	20..43	CDD:279035	18/22 (82%)
RYBP	NP_001286742.1	RanBP2-type Zn finger	23..42	CDD:275377	16/18 (89%)
YAF2	XP_011536030.1	zf-RanBP	20..43	CDD:279035	18/22 (82%)
YAF2	XP_011536030.1	RanBP2-type Zn finger	23..42	CDD:275376	16/18 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141019
Domainoid	1	1.000	51	1.000	Domainoid score	I11598
eggNOG	1	0.900	-	-		E1_KOG4477
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	125	1.000	Inparanoid score	I4714
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49670
OrthoDB	1	1.010	-	-		D1634090at2759
OrthoFinder	1	1.000	-	-		FOG0003518
OrthoInspector	1	1.000	-	-		otm41962
orthoMCL	1	0.900	-	-		OOG6_108317
Panther	1	1.100	-	-	O	PTHR12920
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5806
SonicParanoid	1	1.000	-	-		X3403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840