Protein Alignment KCNJ3 and Irk2

DIOPT Version :10

• Sequence 1: NP_002230.1
• Gene: KCNJ3 / 3760
• HGNCID: 6264
• Length: 501
• Species: Homo sapiens
• Sequence 2: NP_001287485.1
• Gene: Irk2 / 42770
• FlyBaseID: FBgn0039081
• Length: 454
• Species: Drosophila melanogaster
• Alignment Length: 356
• Identity: 157/356 - (44%)
• Similarity: 226/356 - (63%)
• Gaps: 11/356 - (3%)

Human    40 KKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWV 104
            ::.|:|.|.|||.|||...:|.....|:|.|::||:||.:|||.|..|.|::.::|||.|.:||:
  Fly    93 RRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWL 157

Human   105 IAYTRGDLNKAHV------GNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFL 163
            |.||.|||.:.|:      ..:.|||:.:..|.|.|||.|||:.|||||.|..:.:|||.|.:..
  Fly   158 IIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMC 222

Human   164 FQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQI 228
            ||||.|.:..||:.|.:|.||::.|:||:||:||:||||..|||.|:||||||::|.||::.|.:
  Fly   223 FQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGV 287

Human   229 RCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQF 293
            |.:|::::.|.|||.:.....||::|.......||.:.|:.|.|.||..||.|:|:...|..::|
  Fly   288 RAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKF 352

Human   294 EIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGF--FKVDYSQFHATFEVPTPPY 356
            ||||||||.||:||.:.|||:||...|:||||||.||:...:..  :::||::|:.|.:|.||..
  Fly   353 EIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFNETTQVDTPLC 417

Human   357 SVKEQEEMLLMSSPLIAPAITNSKER---HN 384
            |.:|..|:..:......||.|....|   ||
  Fly   418 SARELNEIYKIQEGFRTPAETTFTMRQLSHN 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNJ3	NP_002230.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		157/356 (44%)
		IRK	47..187	CDD:460023	66/145 (46%)
		Selectivity filter. /evidence=ECO:0000250	143..148		4/4 (100%)
		Polyphosphoinositide (PIP2)-binding. /evidence=ECO:0000250|UniProtKB:P63251	182..209		16/26 (62%)
		IRK_C	194..364	CDD:465439	78/171 (46%)
Irk2	NP_001287485.1	IRK	100..246	CDD:460023	66/145 (46%)
		IRK_C	253..424	CDD:465439	78/170 (46%)