DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNJ3 and Irk3

DIOPT Version :9

Sequence 1:	NP_002230.1	Gene:	KCNJ3 / 3760	HGNCID:	6264	Length:	501	Species:	Homo sapiens
Sequence 2:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster

Alignment Length:	383	Identity:	114/383 - (29%)
Similarity:	198/383 - (51%)	Gaps:	47/383 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    17 TSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWR 81
            |...|||  |:....|..     ::...|.::|||:.||....:..::.||:.||.|||::|:|:
  Fly    96 TPDLGSG--PRTSSSDGL-----RRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWK 153

Human    82 WNLFIFILTYTVAWLFMASMWWVIAYTRGDL------NKAHVGNYTPCVANVYNFPSAFLFFIET 140
            :.|.:|:.:|.::||..|::.:|:||:.||.      .|.......||:..|:::.:..::.:||
  Fly   154 YMLTLFLGSYFLSWLLFAALCYVVAYSHGDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVET 218

Human   141 EATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMR 205
            :.|:|:|.:|.:::|||.|.||:.|.:..::::..::..::.|.::|.::...|.||:.|||..|
  Fly   219 QTTLGFGEKYASEECPETIFLFVMQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYR 283

Human   206 DGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTI 270
            ||:|.|:|||.:.|....:.::||..::..::|.|||.:. ..:||.:   .|..:..::.|..:
  Fly   284 DGRLCLLFRVCDPREQQSIESKIRVYIIVDKRTREGETIK-SHVELKL---EGNGEQIILWPDVV 344

Human   271 CHVIDAKSPFYDLSQ----RSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVI 331
            |||||..||   |||    :.....|||:.|.:.|....|....:|:|||...|:.||.||..:|
  Fly   345 CHVIDETSP---LSQFTTAKLFNAAQFELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNII 406

Human   332 --SLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVE 387
              ..:...:.|||..|:.|..|..|                     :||.|..|..:|
  Fly   407 HYDAQNERYIVDYENFNRTISVDMP---------------------MTNPKNDHLKLE 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNJ3	NP_002230.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		6/22 (27%)
		IRK	47..187	CDD:395797	43/145 (30%)
		Selectivity filter. /evidence=ECO:0000250	143..148		2/4 (50%)
		IRK_C	194..364	CDD:407551	58/175 (33%)
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	102/340 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020