DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d2 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	529	Identity:	141/529 - (26%)
Similarity:	259/529 - (48%)	Gaps:	62/529 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WTILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALADIYARHEGK 66
            |.::.|.|:  |||.|....:..:::||:   |...|...:.|::...|.|.....:...:: |:
Human    12 WVLVATSLV--LLYIYGTHSHKLFKKLGI---PGPTPLPFLGTILFYLRGLWNFDRECNEKY-GE 70

  Fly    67 IVGIYMLNKRSILIRDAQLARQIMTSDFASFHDRGVYVDEDKDPLSANLFNLRGA-------SWR 124
            :.|:|...:..::|.|..:.:.::..:..|       |..::.||....| |:.|       .|:
Human    71 MWGLYEGQQPMLVIMDPDMIKTVLVKECYS-------VFTNQMPLGPMGF-LKSALSFAEDEEWK 127

  Fly   125 NLRQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMTTYAVDIIGSVIFGLE 189
            .:|..|:|:|:|.|.|.|...|...||.||:.|....:.|..:.:||....|.:|:|...:||:.
Human   128 RIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVN 192

  Fly   190 IDSFRNPKNEF----REISSSTSRDESLLLKIHNMSMF-ICPPIAKLMNRLGYESRILT-----S 244
            :||..||::.|    :::......|..|||    :|:| ...|:.:.:| :|...:.:|     |
Human   193 LDSLNNPQDPFLKNMKKLLKLDFLDPFLLL----ISLFPFLTPVFEALN-IGLFPKDVTHFLKNS 252

  Fly   245 LRDMMKRTIEFREEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIEKIAAQAF 309
            :..|.:..::.:::|.|   |..|.:|..:|:            .||...  |::|..::.||:.
Human   253 IERMKESRLKDKQKHRV---DFFQQMIDSQNS------------KETKSH--KALSDLELVAQSI 300

  Fly   310 LFYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICI 374
            :...|..::|:....|.:|||:.:|::.::.|||:||||..     |...||:|:..:::||:.:
Human   301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPN-----KAPVTYDALVQMEYLDMVV 360

  Fly   375 METIRKYPGLPFLNRECTEDYPVPGTNHIIAKGTPILISLFGMQRDPVYFPNPNGYDPH-RFDSN 438
            .||:|.:|.:..:.|.|.:|..:.|.  .|.||..:::.::.:..||.|:..|..:.|. ||...
Human   361 NETLRLFPVVSRVTRVCKKDIEINGV--FIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKK 423

  Fly   439 NM-NYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFDAAPVLVTKE 502
            |. :.|...|:|||.|||:||.:|....|.|:||.:.|.||........::..:.|..|:|..::
Human   424 NKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEK 488

  Fly   503 PLKLRLTKR 511
            |:.|::..|
Human   489 PIVLKVHLR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	125/459 (27%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	131/492 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820