DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6d2 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	523	Identity:	134/523 - (25%)
Similarity:	260/523 - (49%)	Gaps:	45/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WTILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALADI-YARHEG 65
            ||  |.:|:..||:.|....:..:.:||:   |...|:..:.|::...:  |:...|: .|:..|
Zfish    11 WT--LVVLVITLLFIYGVWPHRFFIKLGI---PGPRPWPFVGTLLSYAK--GLCNFDMECAKKYG 68

  Fly    66 KIVGIYMLNKRSILIRDAQLARQIMTSD-FASFHDRGVYVDEDKDPLSANLFNLRGASWRNLRQK 129
            |:.|||......:::.|.::.:.::..: :::|.:|.........|.|..:..::...|:.:|..
Zfish    69 KVWGIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSDGIIMVKDERWKRMRST 133

  Fly   130 LTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMTTYAVDIIGSVIFGLEIDSFR 194
            |:|.|:||::|.:|.......|:.::::: ..|....|:||:|:..|::|:|.|..|.::|||..
Zfish   134 LSPYFTSGRLKEIFPIAMTHADRFIKNMQ-KKDPEQPVKIKEVVAPYSLDVITSSSFSVDIDSIN 197

  Fly   195 NPKNEF----REISSSTSRDESLLLKIHNMSMFICPPIAKLMNRLG---YESRILTSLRDMMKRT 252
            ||::.|    ::.......:..|||      :.:.|.:|..:.::|   :....:.....::|:
Zfish   198 NPEDPFVINVKKFIQFNMFNPLLLL------ILLFPSLAIPLKKMGVTLFSKSAMDFFYSVLKK- 255

  Fly   253 IEFREEHNVV---RKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIEKIAAQAFLFYVA 314
              .:::||..   |.|.|:|:::    .:|  .|||:.|.:|:::..|.::..:|.:|:.:|.:.
Zfish   256 --IKDDHNKESEGRVDFLKLMLQ----NQI--PDDQIQDSDTSEQPAKGLTDHEILSQSLVFILG 312

  Fly   315 GSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICIMETIR 379
            |.|:|:....|.||.|:..|:.|::..||:|     .|.......||:|:..:.:|::.|.|::|
Zfish   313 GYETTSTTLTFLLYNLATNPDCLEKLVEEID-----KNFPLDTPITYDALMRMDYLEMAINESMR 372

  Fly   380 KYPGLPFLNRECTEDYPVPGTNHIIAKGTPILISLFGMQRDPVYFPNPNGYDPHRFD-SNNMNYD 443
            ..|..|.|.|...:...:.|..  |.:||.:.|..:.:..||..:.:|..:.|.||. .|...:.
Zfish   373 LLPTAPRLERSAKKTVVINGLT--IPEGTLVGIPTYVLSHDPDIWESPGEFRPERFSPENKSEFL 435

  Fly   444 QAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFDAAPVLVTKEPLKLRL 508
            |.|::|||.|||:||.:|...:..|:.|.|:|.||.:  ...||.:...:.......|.|:.|:|
Zfish   436 QYAFIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSV--ETCKETQIPLEMNVTFQPKVPITLKL 498

  Fly   509 TKR 511
            ..|
Zfish   499 IPR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	116/452 (26%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	120/473 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.910