DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d2 and Cyp3a73

DIOPT Version :9

Sequence 1:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	XP_038945885.1	Gene:	Cyp3a73 / 498198	RGDID:	1595705	Length:	504	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	151/528 - (28%)
Similarity:	265/528 - (50%)	Gaps:	60/528 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WTILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALADIYARHEGK 66
            |.:|..||:  |.||:..|.:..:::.|: ..|..:||  :.||:...|.|.....:.|.:. ||
  Rat    12 WLLLAIILV--LFYRFGTRTHGIFKKQGI-PGPKPLPF--LGTVLNYYRGLWKFDMECYKKC-GK 70

  Fly    67 IVGIYMLNKRSILIRDAQLARQIMTSD-FASFHDR------GVYVDEDKDPLSANLFNLRGASWR 124
            |.|::........|.|.::.:.::..: |:.|.:|      |:        :|.::...:...|:
  Rat    71 IWGLFDGQTPVFAIMDTEMIKSVLVKECFSVFTNRRNIGPVGI--------MSKSISVAKDEEWK 127

  Fly   125 NLRQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMTTYAVDIIGSVIFGLE 189
            ..|..|:|:|:||::|.||..|:..||.||::|:..:::...:.:|:|...|::|:|.|..|.:.
  Rat   128 RYRAFLSPTFTSGRLKEMFPIIEHYGDILVKYLKQKVEKGKPLAMKEVFGAYSMDVITSTSFEVN 192

  Fly   190 IDSFRNPKNEFREISSSTSR---DESLLLKIHNMSMFICP---PIAKLMNRLGYESRILTSLRDM 248
            |:|..|||:.|.|......|   .:.|.|     |:.:.|   ||.:::|...:....:...:..
  Rat   193 INSINNPKDPFVEKVKKFQRFDFFDPLFL-----SVVLFPFLTPIYEMLNICLFPKDSVAFFQKF 252

  Fly   249 ---MKRT-IEFREEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIEKIAAQAF 309
               ||:| ::.:.:|.|   |.|||::...|..|     |:|        ..|::|..:|.|||.
  Rat   253 VYRMKQTRLDSKHKHRV---DFLQLMMNAHNNSK-----DKV--------SHKALSDIEIVAQAI 301

  Fly   310 LFYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICI 374
            :|..|..|:|::..:|.||.|:.:|:..|:.|||:|..|  .|..|.   ||:.|.::::||:.:
  Rat   302 IFIFASYETTSSTLSFVLYSLATHPDSQKKLQEEIDRAL--PNKAPP---TYDTVMEMEYLDMVL 361

  Fly   375 METIRKYPGLPFLNRECTEDYPVPGTNHIIAKGTPILISLFGMQRDPVYFPNPNGYDPHRFDSNN 439
            .||.|.||....|.|.|.:|..:.|.  .|.||:.::|..:.:|.||.::|.|..:.|.||...|
  Rat   362 NETPRLYPIGYRLERVCKKDIKLDGV--FIPKGSVVMIPFYTLQHDPQHWPEPEEFLPERFSKEN 424

  Fly   440 M-NYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFDAAPVLVTKEP 503
            . :.|...|:|||.|||:||.:|...:|.|:|:.|:|.||........::..:.....:...::|
  Rat   425 KGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQLCEETQIPLKLSRQRLFGPEKP 489

  Fly   504 LKLRLTKR 511
            :.|::..|
  Rat   490 IVLKVVPR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	132/458 (29%)
Cyp3a73	XP_038945885.1	CYP3A	67..493	CDD:410743	132/462 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010