DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d2 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	536	Identity:	152/536 - (28%)
Similarity:	263/536 - (49%)	Gaps:	71/536 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WTILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIP---FGVMDTVMKQERSLGMALADIYARH 63
            ||  |..|:..|||.|....:..:::||:   |...|   ||...:..|...:..|..|..|
Zfish    11 WT--LVFLVITLLYMYGVWPHGFFKKLGI---PGPRPWPFFGTFLSYTKGFFNFDMECAKKY--- 67

  Fly    64 EGKIVGIYMLNKRSILIRDAQLARQIMTSD-FASFHDRGVYVDEDKDPLSANLFNLRGASWRNLR 127
             ||:.|||......:::.|.::.:.||..: :::|.:|.....:...||:..:..::...|:.:|
Zfish    68 -GKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADGISAVKDERWKRIR 131

  Fly   128 QKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMTTYAVDIIGSVIFGLEIDS 192
            ..|:|.|:||::|.:|.......|:.::::: ..|....|:||:|:..|::|::.|..|.::|||
Zfish   132 GTLSPYFTSGRLKEIFPIAMTHADRFIKNMQ-KRDHEQPVKIKEVVAPYSLDVVTSSSFSVDIDS 195

  Fly   193 FRNPKNEFREISSSTSRDESLLLKIHNMSMF-----------ICPPIAKLMNRLGYE--SRIL-- 242
            ..||             |:..:..|.|...|           :.|.||.|:.::|..  ||.:
Zfish   196 INNP-------------DDPFVTNIKNFLKFSLFSPLILFLTLFPSIANLLGKMGISVFSRSIMN 247

  Fly   243 ---TSLRDMMKRTIEFREEH--NVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIE 302
               |:||       :.::||  :..|.|.|:|:|:    .:|  .|||..| .|:::.:|.::..
Zfish   248 FFYTALR-------KIKDEHKDSNGRVDFLRLMIQ----NQI--PDDQAKD-TTSEQPVKGLTDH 298

  Fly   303 KIAAQAFLFYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDL 367
            :|.:|:|:|.:.|.|:|:...:|.|:.|:..|:.|::..||:|     .|.......:|:|:..:
Zfish   299 EILSQSFIFILGGYETTSTTLSFLLHNLATNPDCLEKLVEEID-----KNFPLDTPISYDALMKM 358

  Fly   368 KFLDICIMETIRKYPGLPFLNRECTEDYPVPGTNHIIAKGTPILISLFGMQRDPVYFPNPNGYDP 432
            .:|::.|.|::|..|..|.|.|.|.:...:.|..  |.|.|.:.|..:.:.|||..:.:|..:.|
Zfish   359 DYLEMSINESMRLLPTAPRLERVCKKTVELNGIT--IPKDTLVAIPTYVLNRDPQLWDSPQEFRP 421

  Fly   433 HRFD-SNNMNYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFDAAP 496
            .||. .|...:.|.|:||||.|||:||.:|...:..|:.|.|:|.||.|  ...||.:...:..|
Zfish   422 ERFSPENKSEFLQYAFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSL--ETCKETQIPLELTP 484

  Fly   497 VLVTKEPLKLRLTKRK 512
            |...|.|:.|:||.||
Zfish   485 VFQPKVPITLKLTPRK 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	129/462 (28%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	138/498 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820