DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6d2 and Cyp310a1

DIOPT Version :9

Sequence 1:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_609891.1	Gene:	Cyp310a1 / 35115	FlyBaseID:	FBgn0032693	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	151/531 - (28%)
Similarity:	266/531 - (50%)	Gaps:	65/531 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWTILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALADIYARHEG 65
            || :||.||:...::..|:..|:||:|.|...|.|.|.:..:....::|.....|:.:.|...:.
  Fly     1 MW-LLLPILLYSAVFLSVRHIYSHWRRRGFPSEKAGITWSFLQKAYRREFRHVEAICEAYQSGKD 64

  Fly    66 KIVGIYMLNKRSILIRDAQLARQIMTSDFASFHD-RGVYVDEDKDPLSANLFNLRGASWRNLRQK 129
            :::|||...:..:|:|:.:||:.|:......|.: :..|:.              |....||.:|
  Fly    65 RLLGIYCFFRPVLLVRNVELAQTILQQSNGHFSELKWDYIS--------------GYRRFNLLEK 115

  Fly   130 LTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQS-----DEVEIKDVMTTYAVDIIGSVIFGLE 189
            |.|.|.:.::..|||.:..|||.|:.||   ||:.     .||:|:..:..|:|:||.::|:||:
  Fly   116 LAPMFGTKRLSEMFGQVQKVGDHLIHHL---LDRQGQGCPQEVDIQQKLRVYSVNIIANLIYGLD 177

  Fly   190 IDSFRNPKNEFREISSSTSRDESLLLKIHNMSMFICPPIAKLMNRLGYESRILTSLRDMMKRTIE 254
            |::|   ::|...::|..|..::.:...             .:.||..:|.....|||::|:::|
  Fly   178 INNF---EHEDHILTSYLSHSQASIQSF-------------TLGRLPQKSSYTYRLRDLIKQSVE 226

  Fly   255 FREEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIEKIAAQAFLFYVAGSEST 319
            .||:|.::|||:||||:|.||..::..|.   |.:|...:..|.:||:::|..|........::.
  Fly   227 LREDHGLIRKDILQLLVRFRNGNEVSGDK---WQLEPINDADKLLSIKRLAKVAEDLLKVSLDAV 288

  Fly   320 AAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICIMETIRKYPGL 384
            |:...|||.|:...|.::::.:.|:     |.......:..:|.:..|:::|:|:.||:||||.|
  Fly   289 ASTVTFTLLEILQEPLIVEKLRAEI-----KELSNENGQLKFEELNGLRYMDMCLKETLRKYPPL 348

  Fly   385 PFLNRECTEDYPVPGTNHIIAKGTPILISLFGMQRDPVYFPNPNGYDPHRF-----------DSN 438
            |.:.|.|.:.|.:|.:...|.:|..:::.|..|.||..||..|..|.|.||           |..
  Fly   349 PIIERVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSEPMKYKPLRFLQTANDVGQCEDKT 413

  Fly   439 NMNYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANF--DLVQSPRKEVEFRFDAAPVLVTK 501
            ..|    .::.||.|...|:.....|:..|||:.|:|.||  :|..:..|.::.....||.:.||
  Fly   414 KSN----VFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLELDANQVKTLKVSHRPAPFIHTK 474

  Fly   502 EPLKLRLTKRK 512
            :.||::|.:|:
  Fly   475 DGLKVKLKRRE 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	130/459 (28%)
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	122/429 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469017
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	156	1.000	Inparanoid score	I1665
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900