DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6d2 and Cyp28d1

DIOPT Version :9

Sequence 1:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	125/515 - (24%)
Similarity:	230/515 - (44%)	Gaps:	62/515 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TILLTI-LIAGLLYRYVKRHYTHWQRLGVDEEPAKI-PF-GVMDTVMKQERSLGMALADIYARHE 64
            |.|..| .|..|:|.::..::::|::.|:  ..||. || |...:|..|:|::...:.:||.:::
  Fly     6 TALFVIAAILALIYVFLTWNFSYWKKRGI--PTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYK 68

  Fly    65 G--KIVGIYMLNKRSILIRDAQLARQIMTSDFASFHDRGV--YVDEDKDPLSA-NLFNLRGASWR 124
            .  .|||::......:::...:.|.:|..|||.||||..:  :.|...||:.| |.|.|.|.:|:
  Fly    69 NTDSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAWK 133

  Fly   125 NLRQKLTPSFSSGKIKGMFGTIDDVGDKLVQHL--EGALDQSDEVEIKDVMTTYAVDIIGSVIFG 187
            ..|.::||..|:.::|..:.....|..|.|:::  :..:..:..:..||:...|..::|...:.|
  Fly   134 ERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLG 198

  Fly   188 LEIDSFR-NPKNEFREISSSTSR--DESLLLKIHNMSMFICPPIAKLMNRLGYESRILTSLRDMM 249
            :...||. ||    ..:...|.|  ::|.....:.:...:.|||.|..:...:...:.....|:|
  Fly   199 ISAQSFTDNP----TPMVGMTKRVFEQSFGFIFYTVVANLWPPITKFYSVSLFAKDVAAFFYDLM 259

  Fly   250 KRTIEFREEHNVV--RKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIEKIAAQAFLFY 312
            ::.|:.|.|....  |.|.|..:::|                    ::.|.::..::.:....|.
  Fly   260 QKCIQVRRESPAAQQRDDFLNYMLQL--------------------QEKKGLNAAELTSHTMTFL 304

  Fly   313 VAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICIMET 377
            ..|.|:||.....||..|:..|:...:.:||:...          ..|:|.:.:|.|.:.||.||
  Fly   305 TDGFETTAQVLTHTLLFLARNPKEQMKLREEIGTA----------ELTFEQISELPFTEACIHET 359

  Fly   378 IRKYPGLPFLNRECTEDYPVPGTNHIIAK---GTPILISLFGMQRDPVYFPNPNGYDPHRFDSNN 439
            :|.:..:....:..||...:...|.:..|   |..::|.:..:..||.|:..|..:.|.||  .|
  Fly   360 LRIFSPVLAARKVVTEPCELTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERF--LN 422

  Fly   440 MN------YDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFD 493
            :|      .||..:..||:|||.|..:|......|.|:.:|:.|||:..:|:...:...|
  Fly   423 INGGAKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEID 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	107/450 (24%)
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	116/477 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460857
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900