DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d2 and Cyp28d2

DIOPT Version :9

Sequence 1:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	117/516 - (22%)
Similarity:	230/516 - (44%)	Gaps:	69/516 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPF-GVMDTVMKQERSLGMALADIYARHE--G 65
            ::||:|:  |:|.::..::.:|::.|:...|. .|| |...::..::|::...:.|||.:::  .
  Fly    10 LVLTLLV--LVYVFLTWNFNYWRKRGIKTAPT-WPFVGSFPSIFTRKRNIAYDIDDIYEKYKDTD 71

  Fly    66 KIVGIYMLNKRSILIRDAQLARQIMTSDFASFHDR--GVYVDEDKDP-LSANLFNLRGASWRNLR 127
            .:||::......:|:...:...:|..:||.|||:.  ..:|::..|. |..|.|.|.|..|:..|
  Fly    72 NMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPFVLTGDEWKERR 136

  Fly   128 QKLTPSFSSGKIKGMFGTIDDVGDKLVQHL--EGALDQSDEVEIKDVMTTYAVDIIGSVIFGLEI 190
            .::.|:.|..::|.::.....|..|.|:::  :..:..|:.::..|:...|..:::.....|:..
  Fly   137 SEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTTEVVSDCGLGVSA 201

  Fly   191 DSFRNPKNEFREISSSTSRDESLLLKIHNMSMFICPPIAKLMNRLGYES------RILTSLRDMM 249
            .||.:...                            |:.|::.|:...|      .::|:|...:
  Fly   202 QSFTDTPT----------------------------PLLKMIKRVFNTSFEFIFYSVVTNLWQKV 238

  Fly   250 KRTIE---FREEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIEKIAAQAFLF 311
            ::...   |.:|..|...|:::..|.||......:.||.:..|...||: |.:..:.|......|
  Fly   239 RKFYSVPFFNKETEVFFLDIIRRCITLRLEKPEQQRDDFLNYMLQLQEK-KGLHTDNILINTMTF 302

  Fly   312 YVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICIME 376
            .:.|.|:||...|..:..|...||...:.::|:.:.          ..|::.:.:|..||.||.|
  Fly   303 ILDGFETTALVLAHIMLMLGRNPEEQDKVRKEIGSA----------DLTFDQMSELPHLDACIYE 357

  Fly   377 TIRKYPGLPFLNRECTEDYPVPGTN----HIIAKGTPILISLFGMQRDPVYFPNPNGYDPHRFDS 437
            |:|.:.......:..||.:.....|    | :..|..:.|.:..:..||.|:.:|..:.|.||..
  Fly   358 TLRLFSPQVAARKLVTEPFEFANKNGRTVH-LKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLE 421

  Fly   438 NN----MNY-DQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFD 493
            :|    .:| |:..|:.||:|||||..:|......|.|:.:||.||::..:|:...:.:.|
  Fly   422 SNGGGMKSYRDRGVYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEIKVNPKTRSDNQID 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	102/452 (23%)
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	109/477 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460861
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900