DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d2 and Cyp6t1

DIOPT Version :9

Sequence 1:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	163/535 - (30%)
Similarity:	259/535 - (48%)	Gaps:	54/535 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ILLTILIAG-------LLYRYVKRHYTHWQRLGVDEEPAKIPF-GVMDTVMKQERSLGMALADIY 60
            :||.:::.|       :::.:...|:.||:||||...|| .|| |.:..:::.....|....::|
  Fly    18 VLLPVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPA-APFVGNVWNLLRGACCFGDQFRELY 81

  Fly    61 ARHEG---KIVGIYMLNKRSILIRDAQLARQIMTSDFASFHDRGVYVDEDKDPL-SANLFNLRGA 121
            ...|.   ..|||.:|:..::|:||..|.::||..|||.|..|....|...|.: |.|||..:..
  Fly    82 ESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSRFETTDPTCDTMGSQNLFFSKYE 146

  Fly   122 SWRNLRQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSD--EVEIKDVMTTYAVDIIGSV 184
            :||...:...|.|::||::.|:|.::::|.||.:|:|..|...|  |:|:|.:...:..|||.|:
  Fly   147 TWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFTTDIIASL 211

  Fly   185 IFGLEIDSFRNPKNEFRE--ISSSTSRDESLLLKIHNMSMFICPPIAKLMNRLG---YESRILTS 244
            .||:|..|.:||:.|||.  |..:..|.:.||   |..:||..|   :|.:|:|   |.......
  Fly   212 AFGIEAHSLQNPEAEFRRMCIEVNDPRPKRLL---HLFTMFFFP---RLSHRVGTHLYSEEYERF 270

  Fly   245 LRDMMKRTIEFREEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIEKIAAQAF 309
            :|..|...:..|.|....|.|::.:.::|:.|             |.|:..:.....  .||||.
  Fly   271 MRKSMDYVLSQRAESGENRHDLIDIFLQLKRT-------------EPAESIIHRPDF--FAAQAA 320

  Fly   310 LFYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDR-FTYEAVQDLKFLDIC 373
            ...:||.:::::...|.||||:....:....:.|:.|.|.    ..:|| .:.:.|..|.:|...
  Fly   321 FLLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQ----SSQDRQLSCDTVTGLVYLRQV 381

  Fly   374 IMETIRKYPGLPFLNRECTE--DYPVP----GTNHIIAKGTPILISLFGMQRDPVYFPNPNGYDP 432
            :.|.:|.||...||:|.|..  .|.:.    |:...:..|||:.||:.|:.||..|:|||..:||
  Fly   382 VDEVLRLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDP 446

  Fly   433 HRFDS-NNMNYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFD-AA 495
            .||.: ....:....|:|||.|||.||...:|::..||.:..||.:|.:....|...|.||| .|
  Fly   447 ERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDPKA 511

  Fly   496 PVLVTKEPLKLRLTK 510
            .||.......||..|
  Fly   512 FVLTAHNGTYLRFVK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	142/460 (31%)
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	141/448 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461003
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900