DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6d2 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	528	Identity:	156/528 - (29%)
Similarity:	270/528 - (51%)	Gaps:	57/528 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WTILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALADI-YARHEG 65
            ||  |.:|:..||..|....:..:::||: ..|..:||  :.|.:..  |.|:...|| .::..|
Zfish    11 WT--LVVLVITLLLIYGVWPHGFFKKLGI-PGPRPLPF--VGTALSY--SKGICNFDIECSKKYG 68

  Fly    66 KIVGIYMLNKRSILIRDAQLARQIMTSD-FASFHDRGVYVDEDKDPLSANLFNLRGASWRNLRQK 129
            |:.|||......:|:.|.::.:.|:..| :::|.:|.....:...|.:..:..::...||.:|..
Zfish    69 KVWGIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNRRNMNPDLVGPFADGITLVKDERWRRIRSS 133

  Fly   130 LTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMTTYAVDIIGSVIFGLEIDSFR 194
            |:|.|:||::|.:|.......|:.::::| ..|.:..::||||:..|::|::.|..|.::.||..
Zfish   134 LSPYFTSGRLKEIFPIAMTHADRFIKNME-KKDPNLPLKIKDVVAPYSLDVVASSSFSVDFDSIN 197

  Fly   195 NPKNEFREISSSTSRDESLLLKIHNMS-MFI----CPPIAKLMNRLGYE--SRILTSLRDMMKRT 252
            ||.:.|  ::|..|     ...|:.:| :|:    ||..|.|:.::|..  ||..|..  ..|..
Zfish   198 NPDDPF--VTSIKS-----FFNINPLSPLFLLLAFCPSAANLLAKMGISVFSRSTTDF--YYKAL 253

  Fly   253 IEFREEHNVV--RKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQ-LKSMSIEKIAAQAFLFYVA 314
            .:.::|||..  |.|.|:|:|:    .:|  .||||.|  ||.|| :|.::..:|.:|:|:|.:.
Zfish   254 RKIKDEHNESNGRVDFLKLMIQ----NQI--PDDQVKD--TASEQPVKGLTDHEILSQSFIFILG 310

  Fly   315 GSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICIMETIR 379
            |.|:|:...::.||.|:..|:.|::..||:|     .|.......||:|:..:.:|::.|.|::|
Zfish   311 GYETTSTTLSYLLYNLATNPDCLEKLVEEID-----KNFPLDIPITYDALMRMDYLEMAIHESMR 370

  Fly   380 KYPGLPFLNRECTEDYPVPGTNHIIAKGTPILISLFGMQRDPVYFPNPNGYDPHRFD-SNNMNYD 443
            .:|..|.|.|.|.:...:.|..  |.|.|.:.|.|:.:.|||..:.:||.:.|.||. .:....:
Zfish   371 VFPAGPRLERVCKKTVEINGIT--IPKNTLVGIPLYVLSRDPDLWESPNEFKPERFSPESKTEIN 433

  Fly   444 QAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDL-----VQSPRKEVEFRFDAAPVLVTKEP 503
            |.|:||||.|||:||.:|...:..|:.|.|:|..:.:     .|.|   |:..|...|    |.|
Zfish   434 QCAFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKYTVETCKETQIP---VQLNFFFQP----KVP 491

  Fly   504 LKLRLTKR 511
            :.|:|..|
Zfish   492 ITLKLIPR 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	136/457 (30%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	145/493 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.910