DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d2 and Cyp6a16

DIOPT Version :9

Sequence 1:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	171/540 - (31%)
Similarity:	272/540 - (50%)	Gaps:	94/540 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WTILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFG---VMDTVMKQERSLGMALADIYARH 63
            :|:||...:...|..|::..:|:|:..|:.:......||   .:.:|...|     .|.:.|...
  Fly     3 FTLLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQSVHYSE-----LLQETYDAF 62

  Fly    64 EG--KIVGIYMLNKRSILIRDAQLARQIMTSDFASFHDRGVYVDEDKDPLSANLFNLRGASWRNL 126
            .|  |:.|.|:..:...::.|..|.:.::..||.:|.||..:   ..|||:||||||:|..||||
  Fly    63 RGSAKVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSF---HGDPLTANLFNLQGEEWRNL 124

  Fly   127 RQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALD-----QSDEVEIKDVMTTYAVDIIGSVIF 186
            |.||:|:|:|||:|.||||:..|    .|.|.|..|     |...:|:.|:|..|..|:|||..|
  Fly   125 RTKLSPTFTSGKMKYMFGTVSTV----AQQLGGTFDELVGSQGAVLELHDLMARYTTDVIGSCAF 185

  Fly   187 GLEIDSFRNPKNEFREISSSTSR--DESLLLKIHNMS------------MFICPPIAKLMNRLGY 237
            |.|..|.|.|:.|||::.....|  :.|:..:|..|:            ..:.|.|.|..||:
  Fly   186 GTECSSLREPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKLGLPVRILHPDITKFFNRI-- 248

  Fly   238 ESRILTSLRDMMKRTIEFREEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIE 302
                       ::.|:|.||..|:.|.|.:.||:.||.                 ||..|.:::|
  Fly   249 -----------VRETVELRERENIRRNDFMDLLLDLRR-----------------QENGKGLTME 285

  Fly   303 KIAAQAFLFYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDL 367
            ::|||||:|:|||.|::::..::.|:||:...::.::.:.|::..:.||.     :.||||:.::
  Fly   286 QMAAQAFVFFVAGFETSSSNMSYALFELAKNQDVQQKLRMEINDSIGKHG-----KLTYEAMMEM 345

  Fly   368 KFLDICIMETIRKYPGLPFLNRECTEDYPVP----GTNHIIAKGTPILISLFGMQRDPVYFPNPN 428
            .:||..|.||:||||.|..|.|..:|||.:|    |...::.|||.:.|.:..:..||..:|.|:
  Fly   346 PYLDQTITETLRKYPALSSLTRLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPH 410

  Fly   429 GYDPHRF--DSNNMNYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFR 491
            .:.|.||  |:....: ..|::.||:|||:||.||.|::..||.:..:|.            .||
  Fly   411 EFRPERFAPDACRERH-PTAFLGFGDGPRNCIGLRFGRMQVKVGLITLLR------------RFR 462

  Fly   492 FDAAPVLVTKEPLKLRLTKR 511
            |...|    ..|.:|::|||
  Fly   463 FSLPP----GSPTQLKVTKR 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	153/467 (33%)
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	163/511 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	8.070