DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d2 and Cyp3a16

DIOPT Version :9

Sequence 1:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus

Alignment Length:	521	Identity:	149/521 - (28%)
Similarity:	264/521 - (50%)	Gaps:	46/521 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALADIYARHEGKI 67
            |::|..:|..|||||....:..:::.|: ..|..:||  :.||:...:.|.....:.|.:: ||.
Mouse    11 TLVLLAIILVLLYRYGTCTHGLFKKQGI-PGPKPLPF--LGTVLNYYKGLWKFDMECYEKY-GKT 71

  Fly    68 VGIYMLNKRSILIRDAQLARQIMTSD-FASFHDRGVYVDEDKDP---LSANLFNLRGASWRNLRQ 128
            .|::.......:|.|.:..:.::..: |:.|.:|     :|..|   :|.::...:...|:..|.
Mouse    72 WGLFDGQIPLFVITDPETIKNVLVKECFSVFTNR-----QDFFPVGIMSKSISLAKDEEWKRYRA 131

  Fly   129 KLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMTTYAVDIIGSVIFGLEIDSF 193
            .|:|:|:||.:|.||..|:..||.||::|....::...|.:|||:..|::|:|.|..||:.|||.
Mouse   132 LLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEKGKPVAVKDVLGAYSMDVIISTTFGVNIDSL 196

  Fly   194 RNPKNEFREISSSTSRDESLLLKIHNMSMFICP---PIAKLMNRLGYESRILTSLRDMMKRTIEF 255
            .||::.|.|.:....|.:  .....::|:.:.|   ||.:::|...:....:...:..:.|..|.
Mouse   197 NNPEDPFVENAKKVLRFD--YFDPLSLSVALFPFLTPIYEMLNICMFPKDSIEFFKKFVDRMTEN 259

  Fly   256 R----EEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIEKIAAQAFLFYVAGS 316
            |    ::|.|   |.:.|::...|..|   |.|          ..|::|..:|.||:.:|..||.
Mouse   260 RLDSKQKHRV---DFIYLMMEAYNKSK---DKD----------SHKALSEIEITAQSIIFIFAGY 308

  Fly   317 ESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICIMETIRKY 381
            |:|::..:||:|.|:.:|::.|:.|||:|..|  .|..|.   ||:.|..:::||:.:.||:|.|
Mouse   309 ETTSSILSFTVYSLATHPDIQKKLQEEIDEAL--PNKAPP---TYDTVMAMEYLDMVLNETLRLY 368

  Fly   382 PGLPFLNRECTEDYPVPGTNHIIAKGTPILISLFGMQRDPVYFPNPNGYDPHRFDSNNM-NYDQA 445
            |....|.|.|.:|..:.|.  .|.||:.::|..:.:..||.::|.|..:.|.||...|. :.|..
Mouse   369 PITNRLQRVCKKDVEINGI--YIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDPY 431

  Fly   446 AYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFDAAPVLVTKEPLKLRLTK 510
            .|:|||.|||:||.:|...:|.|:|:.|:|.||........::..:.....:|...:|:.|::..
Mouse   432 VYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQIPLKLSRELLLQPVKPIVLKVVP 496

  Fly   511 R 511
            |
Mouse   497 R 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	131/452 (29%)
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	139/487 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820