DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt317A1 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_001286734.1	Gene:	Ugt317A1 / 37590	FlyBaseID:	FBgn0040091	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_444414.2	Gene:	Ugt2a1 / 94215	MGIID:	2149905	Length:	528	Species:	Mus musculus

Alignment Length:	539	Identity:	126/539 - (23%)
Similarity:	238/539 - (44%)	Gaps:	74/539 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ILLAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHG-LGESLDNVT 72
            |||..|.::|..:|....:|: :| :...|:..::.::.||..:||.:.|....| |..:..:::
Mouse     5 ILLCSLQISLLGMSLGGNVLI-WP-MEGSHWLNVKIIIDELLRKEHNVTVLVASGALFITPSSIS 67

  Fly    73 ETVTAEF---PFWSELQKQAAPKGNLADLGLLPIEKLRQSLASVG------ARALD--HFLAQEP 126
            .::|.|.   ||..|..:..     :.|..|..:|. |.|.:::.      |:.::  |.:::..
Mouse    68 PSLTFEIYPVPFGKEKIESV-----IKDFVLTWLEN-RPSPSTIWTFYKEMAKVIEEFHLVSRGI 126

  Fly   127 IQKLLK----MSYLEFD-FDVILVDYFYTEALLALGALHQRPVVGIISTDFG---------NYMD 177
            ...:||    ||.|:.: |:|:|.|..:             |...|::...|         :...
Mouse   127 CDGVLKNEKLMSKLQKEKFEVLLSDPVF-------------PCGDIVALKLGIPFIYSLRFSPAS 178

  Fly   178 AVQE---------ALVPAACSPIDFERDQPEMSFSVRLGNIRTCIARRKQ--FIKDHYGGQEQLV 231
            .|::         :.|||..|.:   .||  |||:.|   :|..|:.|.|  ..:..:...:...
Mouse   179 TVEKHCGKVPFPPSYVPAILSEL---TDQ--MSFTDR---VRNFISYRMQDYMFETLWKQWDSYY 235

  Fly   232 TKYFQLQSSIPELQASQLSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNVKRFLE-EA 295
            ||.....:::.|.. .:..:.|:.::.....|:..:......||||.:..|.||..::.|:: ..
Mouse   236 TKALGRPTTLCETM-GKAEIWLMRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFVQTSG 299

  Fly   296 RPGAIYVQLGNEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQHAVPQIDI 360
            ..|.:...||:  ....|..||.:.:.:..:...|.::|. :..|..:.|..|..:...:||.|:
Mouse   300 EHGIVVFSLGS--MVKNLTDEKANLIASALAQIPQKVLWR-YKGKIPDTLGSNTRLFDWIPQNDL 361

  Fly   361 LAHPRVKAFLTNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGNVTTESLNW 425
            |.||:.:||:|:|....:.|.|...:|::|:|:|..:..|:......|..:::....:|:..|..
Mouse   362 LGHPKTRAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMTSSDLLN 426

  Fly   426 AVDRLLLESHFQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGISSCQLHLFD 490
            |:..::.|..::.....:|....|:|:..|..|:||:.:|.||||...||.....:|..|.|..|
Mouse   427 ALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLD 491

  Fly   491 LFVF-YAGIATLVVSLLVA 508
            :..| .|.:|:.:  ||||
Mouse   492 VIGFLLACVASAI--LLVA 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_001286734.1	Glycosyltransferase_GTB_type	22..477	CDD:299143	110/492 (22%)
Ugt317A1	NP_001286734.1	UDPGT	25..514	CDD:278624	120/523 (23%)
Ugt2a1	NP_444414.2	UDPGT	21..516	CDD:278624	120/523 (23%)
Ugt2a1	NP_444414.2	egt	<267..487	CDD:223071	56/222 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810