Protein Alignment Ugt317A1 and UGT2A3

DIOPT Version :10

• Sequence 1: NP_611694.2
• Gene: Ugt317A1 / 37590
• FlyBaseID: FBgn0040091
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 124/549 - (22%)
• Similarity: 234/549 - (42%)
• Gaps: 57/549 - (10%)

  Fly     8 WILLAILGLALGQISQAAKILVLFPHVNEGHFAVMRTLVTELANREHTIEVYTGHGLGESLDNVT 72
            ::||.:..:..|   ...|:|| :| .:..|:..::.::.||..|.|.:.|.| |. ..||.:..
Human    10 FLLLQLFCVGCG---FCGKVLV-WP-CDMSHWLNVKVILEELIVRGHEVTVLT-HS-KPSLIDYR 67

  Fly    73 ETVTAEFPFWSELQKQAAPKGNLADLGL--LPIEKLRQSLASVGARALDHFLAQEPIQKLLKMSY 135
            :....:|......|.:........||.|  ||.....||:..:.    |.|:......|::..|:
Human    68 KPSALKFEVVHMPQDRTEENEIFVDLALNVLPGLSTWQSVIKLN----DFFVEIRGTLKMMCESF 128

  Fly   136 L----------EFDFDVILVD------YFYTEALLALGALHQRPVVGIISTDFGNYMDAVQEALV 184
            :          |.::||:|:|      ....|.|.....|..|..||      ||...:..:...
Human   129 IYNQTLMKKLQETNYDVMLIDPVIPCGDLMAELLAVPFVLTLRISVG------GNMERSCGKLPA 187

  Fly   185 PAACSPIDFERDQPEMSFSVRLGNIRTCIARRKQFIKDH-YGGQEQLVTKYFQLQSSIPELQASQ 248
            |.:..|:........|:|..|:.|....:... .:|:|: |...|:..:|.....:::.| ...:
Human   188 PLSYVPVPMTGLTDRMTFLERVKNSMLSVLFH-FWIQDYDYHFWEEFYSKALGRPTTLCE-TVGK 250

  Fly   249 LSVLLLNSHVPLITPKVSIQQIIPAGGLHIRGPKELPWNVKRFLEE--------ARPGAIYVQLG 305
            ..:.|:.::.....|:.........||||.:..|.|| .:..:|:|        ...|.:...||
Human   251 AEIWLIRTYWDFEFPQPYQPNFEFVGGLHCKPAKALP-KINFYLQEMENFVQSSGEDGIVVFSLG 314

  Fly   306 NEQACGQLPKEKLDTLFAFFSARKQSIIWTCHDVKTLEGLPKNVMIQHAVPQIDILAHPRVKAFL 370
            :  ....:.:||.:.:.:..:...|.::|. :..|....|..|..:...:||.|:|.||:.|||:
Human   315 S--LFQNVTEEKANIIASALAQIPQKVLWR-YKGKKPSTLGANTRLYDWIPQNDLLGHPKTKAFI 376

  Fly   371 TNGDLLNLQEGIMRNVPILGLPLFQHEARNMELAVRLGVGLQLEEGNVTTESLNWAVDRLLLESH 435
            |:|.:..:.|.|...||::|:|:|..:..|:......|..:::....:|:|.|..|:..::.:|.
Human   377 THGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSS 441

  Fly   436 FQLTIRDVSLEFRDRPLGALASALFWVNYVARHKGGSALRTRGIGISSCQLHLFDLFVF-YAGIA 499
            ::.....:|....|:|:..|..|:||:.:|.||||...||:....::..|.:..|:..| .|.:|
Human   442 YKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVIGFLLACVA 506

  Fly   500 TLVVSLLVALSFGGFYIWNKKNNSKSTKV 528
            |.:      ..|...::::.:..:|:.|:
Human   507 TAI------FLFTKCFLFSCQKFNKTRKI 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt317A1	NP_611694.2	GT1_Gtf-like	25..431	CDD:340817	97/432 (22%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	120/529 (23%)